Dopamine D4 receptor antagonists as treatment for attention deficit-hyperactivity disorder
AssigneeThe McLean Hospital Corporation
InventorsRoss J. Baldessarini, Kehong Zhang, Frank I. Tarazi
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Abstract
A method of inhibiting motor hyperactivity in a mammal exhibiting the symptoms of attention deficit-hyperactivity disorder (ADHD) includes administering to a mammal a dopamine D4 receptor-selective antagonist.
Claims7
A method of inhibiting motor hyperactivity in a mammal exhibiting the symptoms of attention deficit-hyperactivity disorder, said method comprising administering to said mammal a dopamine D4 receptor-selective antagonist having a more than 200 fold greater affinity for D4 receptors than for D2 receptors.
A method of inhibiting motor hyperactivity in a mammal exhibiting the symptoms of attention deficit-hyperactivity disorder, said method comprising administering to said mammal a dopamine D4 receptor-selective antagonist selected from the group consisting of PNU-101958, RBI-257, NGD-94-1, L-745,870, L-750,667, PD-172,938, PNU-101387G, S-18126, NRA-0045, CP-293,019, YM-43611 AND YM-50001.
Dependencies are inferred from the claim text.