Respiratory syncytial virus replication inhibitors

A compound of formula

• a prodrug, addition salt, or stereochemically isomeric form thereof wherein
• —a1═a2—a3═a4— represents a bivalent radical of formula
• —CH═CH—CH═CH— (a-1);
• wherein each hydrogen atom in the radical (a-1)may optionally be replaced by halo, C1-6alkyl, nitro, amino, hydroxy, C1-6alkyloxy, polyhaloC1-6alkyl, carboxyl, aminoC1-6alkyl, mono- or di(C1-4alkyl)aminoC1-6alkyl, C1-6alkyloxycarbonyl, hydroxyC1-6alkyl, or a radical of formula
• wherein Z is O, CH—C(═O)—NR5aR5b, CH2, CH—C1-6alkyl, N—OH or N—O—C1-6alkyl;
• Q is a radical of formula
• wherein;
• Y1 is a bivalent radical of formula —NR2— or —CH(NR2R4)—;
• X1 is NR4, S, S(═O), S(═O)2, O, CH2, C(═O), C(═CH2), CH(OH), CH(CH3), CH(OCH3), CH(SCH3), CH(NR5aR5b), CH2—NR4 or NR4—CH2;
• X2 is a direct bond, CH2, C(═O), NR4, C1-4alkyl-NR4, NR4—C1-4alkyl;
• u is 2or 3;
• v is 2;
• and
• whereby each hydrogen atom in the carbocycles and the heterocycles defined in radicals (b-4), (b-5), and (b-6) may optionally be replaced by R3;
• with the proviso that when R3 is hydroxy or C1-6alkyloxy, then R3 can not replace a hydrogen atom in the α position relative to a nitrogen atom;
• G is C1-10alkanediyl substituted with one or more hydroxy, C1-6alkyloxy, arylC1-6alkyloxy, C1-6akylthio, arylC1-6alkylthio, HO(—CH2—CH2—O)n—, C1-6alkyloxy (—CH2—CH2—O)n— or arylC1-6alkyloxy(—CH2—CH2—O)n—;
• R1 is a monocyclic heterocycle or aryl;
• said heterocycle being selected from piperidinyl, piperazinyl, pyridyl, pyrazinyl, pyridazinyl, pyrimidinyl, furanyl, tetrahydrofuranyl, thienyl, pyrrolyl, thiazolyl, oxazolyl, imidazolyl, isothiazolyl, pyrazolyl, isoxazolyl, oxadiazolyl;
• and each heterocycle may optionally be substituted with 1 or where possible more-substituents selected from halo, hydroxy, amino, cyano, carboxy, C1-6alkyl, C1-6alkyloxy, C1-6alkylthio, C1-6alkyloxyC1-6alkyl, aryl, arylC1-6alkyl, arylC1-6alkyloxy, hydroxyC1-6alkyl, mono- or di(C1-6alkyl)amino, mono- or di(C1-6alkyl)aminoC1-6alkyl, polyhaloC1-6alkyl, C1-6alkylcarbonylamino, C1-6alkyl-SO2—NR5c—, aryl-SO2—NR5c—, C1-6alkyloxycarbonyl, —C(═O)—NR5cR5d, HO(—CH2—CH2—O)n—, halo(—CH2—CH2—O)n—, C1-6alkyloxy(—CH2—CH2—O)n—, arylC1-6alkyloxy(—CH2—CH2—O)n— and mono- or di(C1-6alkyl)amino(—CH2—CH2—O)n—;
• each n independently is 1, 2, 3 or 4;
• R2 is hydrogen, formyl, C1-6alkylcarbonyl, Hetcarbonyl, pyrrolidinyl, piperidinyl, homopiperidinyl, C3-7cycloalkyl substituted with N(R6)2, or C1-10alkyl substituted with N(R6)2 and optionally with a second, third or fourth substituent selected from amino, hydroxy, C3-7cycloalkyl, C2-5alkanediyl, piperidinyl, mono- or di(C1-6alkyl)amino, C1-6alkyloxycarbonylamino, aryl and aryloxy;
• R3 is hydrogen, hydroxy, C1-6alkyl, C1-6alkyloxy, arylC1-6alkyl or arylC1-6alkyloxy;
• R4 is hydrogen, C1-6alkyl or arylC1-6alkyl;
• R5a, R5b, R5c and R5d each independently are hydrogen or C1-6alkyl;
• or
• R5a and R5b, or R5c and R5d taken together form a bivalent radical of formula —(CH2)s— wherein s is 4 or 5;
• R6 is hydrogen, C1-4alkyl, formyl, hydroxyC1-6alkyl, C1-6alkylcarbonyl or C1-6alkyloxycarbonyl;
• aryl is phenyl or phenyl substituted with 1 or more-substituents selected from halo, hydroxy, C1-6alkyl, hydroxyC1-6alkyl, polyhaloC1-6alkyl, and C1-6alkyloxy;
• and
• Het is pyridyl, pyrimidinyl, pyrazinyl, or pyridazinyl.