Kinase inhibitors for the treatment of disease

A compound represented by the general formula II:

• wherein;
• A is NR2;
• R1 is independently selected from the group consisting of halogen, hydroxy, nitro, cyano, hydrocarbyl and substituted hydrocarbyl radicals, wherein said substituted hydrocarbyl may be substituted with heteroatoms selected from the group consisting of halogen, nitrogen, phosphorus, sulfur and oxygen;
• R2 is selected from the group consisting of hydrogen or C1 to C8 alkyl;
• R is morpholinyl;
• R3 and R4, together with the nitrogen atom may form a six-membered heterocyclic ring;
• R5 and R6 are independently selected from the group consisting of hydrogen and alkyl radicals;
• provided that said alkyl radicals may be substituted with from one to three halo, lower alkyloxy or lower alkyl amino radicals;
• a is 1;
• b is 0 or an integer of from 1 to 3;
• the wavy line represents a E or Z bond and Ar is phenyl.