Therapy for cellular accumulation in chronic inflammatory diseases
AssigneesThe Regents of the University of California, La Jolla Institute for Allergy and Immunology
InventorsGary S. Firestein, Nathan J. Zvaifler, Douglas R. Green
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Abstract
The present invention provides a novel method for the treatment of cellular accumulation in chronic inflammatory diseases such as rheumatoid arthritis. The method includes gene delivery and gene expression that is capable of enhancing apoptosis of accumulating cells and those cells which recruit accumulating cells. Also provided are diagnostic methods for detecting cellular accumulation diseases.
Claims19
A method of ameliorating cellular accumulation of apoptosis defective cells in an arthritis in a patient, wherein the arthritis has an etiology associated with a defective apoptosis-regulating gene or polypeptide, the method comprising administering to the site of cellular accumulation in the patient a therapeutically effective amount of a composition comprising a nucleic acid molecule encoding a polypeptide that enhances apoptosis in the apoptosis defective cells, wherein the nucleic acid molecule is operably linked to a promoter, whereby the polypeptide that enhances apoptosis is expressed in the apoptosis defective cells such that the arthritis is ameliorated.
A method of ameliorating cellular accumulation of apoptosis defective cells in an arthritis in a patient having arthritis, wherein the arthritis has an etiology associated with a defective apoptosis-regulating gene or polypeptide, the method comprising administering to the site of cellular accumulation in the patient a therapeutically effective amount of a composition comprising a nucleic acid molecule encoding a polypeptide that enhances apoptosis in the apoptosis defective cell, wherein the nucleic acid molecule is operably linked to a promoter, whereby the polypeptide that enhances apoptosis is expressed in the apoptosis defective cells such that the arthritis is ameliorated.
A method of ameliorating cellular accumulation of apoptosis defective cells in an arthritis in a patient, wherein the arthritis has an etiology associated with a defective apoptosis-regulating p53 gene or polypeptide, the method comprising administering to the site of the arthritis in the patient a therapeutically effective amount of a composition comprising a nucleic acid molecule encoding p53, which enhances apoptosis in the apoptosis defective cells, wherein the nucleic acid molecule is operably linked to a promoter, whereby p53 is expressed in the apoptosis defective cells such that the arthritis is ameliorated.
Dependencies are inferred from the claim text.