Crystalline anthracycline antibiotic and process for producing the same
AssigneeMercian Corporation
InventorsOsamu Johdo, Kiyotomo Nakamura, Takeo Yoshioka
Life of this patent
Estimating the term…
Abstract
Disclosed are a crystalline form of anthracycline antibiotic having specific characteristic 2θ values as measured by the X-ray diffraction method, and a process for producing the crystalline form. This process comprises the step of crystallization involving the combined use of a specific poor solvent for the antibiotic and a good solvent thereof. This crystalline form has excellent chemical and physical properties.
Claims6
A crystalline form of anthracycline antibiotic represented by the following formula (I) and having at least characteristic 2θ values in degrees of 6.18, 7.88, 9.82, 11.60, 13.30, 15.80, 20.88 and 23.12 as measured by an X-ray powder diffraction method:
A process for producing a crystalline form of anthracycline antibiotic represented by the following formula (I) and having at least characteristic 2θ values in degrees of 6.18, 7.88, 9.82, 11.60, 13.30, 15.80, 20.88 and 23.12 as measured by an X-ray powder diffraction method,
- the process comprising the steps of:
- preparing a solution comprising a first solvent comprising 1-butanol, a second solvent which is miscible with the first solvent and capable of dissolving the antibiotic of formula (I), and the antibiotic of formula (I) dissolved therein;
- and
- subjecting the solution to a crystallization treatment, to obtain said crystalline form of the antibiotic of formula (I).
Dependencies are inferred from the claim text.