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US 6,747,011 B1Granted
Antitumor drugs and methods
AssigneeA.P. Group, Inc.
InventorJennifer H. Zhang
Life of this patent
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Abstract
Derivatives of apoptolidin, including skeletal homologues, are potent and selective apoptosis-inducing agents which, unlike apoptolidin, do not undergo isomerization under physiological conditions. These compounds exhibit antitumor properties, often superior to those of apoptolidin, and as such can be used in the treatment of cancer and other hyperproliferative disorders.
Claims17
The compound of formula I or pharmaceutically acceptable esters, ethers, and/or salts thereof:
- wherein:
- n is an integer from 0 to 6,
- m is an integer from 0 to 6, except that m≠0 when n=0, and
- R is a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl, heterocyclyl, alkylcarbonyl, arylcarbonyl, alkoxycarbonyl, aryloxycarbonyl, aminocarbonyl, alkylcarbonyloxy, arylcarbonyloxy, aminocarbonyloxy, or alkylthio.
1 more element
A pharmaceutical composition comprising a pharmaceutically acceptable carrier and as active ingredient the compound of formula I
- wherein:
- n is an integer from 0 to 6,
- m is an integer from 0 to 6, except that m≠0 when n=0, and
- R is a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl, heterocyclyl, alkylcarbonyl, arylcarbonyl, alkoxycarbonyl, aryloxycarbonyl, aminocarbonyl, alkylcarbonyloxy, arylcarbonyloxy, aminocarbonyloxy, or alkylthio.
1 more element
Dependencies are inferred from the claim text.