Methods for treating and preventing alopecia
AssigneeUniversity of Southern California
InventorsKathleen E. Rodgers, Gere S. DiZerega
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Abstract
The present invention provides improved methods, kits, and pharmaceutical compositions for treating and preventing alopecia in a subject in need thereof by administering an effective amount of angiotensinogen, angiotensin I (AI), AI analogues, AI fragments and analogues thereof, angiotensin II (AII), AII analogues, AII fragments or analogues thereof or AII AT2 type 2 receptor agonists to the subject.
Claims6
A method for treating alopecia, comprising administering to a subject in need thereof at least one active agent comprising a sequence of at least seven contiguous amino acids of groups R1-R8 in the sequence of general formula I
- R1—R2—R3—R4—R5—R6—R7—R8
- wherein R1 is selected from the group consisting of H, Asp, Glu, Asn, Acpc (1-aminocyclopentane carboxylic acid), Ala, Me2Gly, Pro, Bet, Glu(NH2), Gly, Asp(NH2) and Suc,
- R2 is selected from the group consisting of Arg, Lys, Ala, Orn, Ser(Ac), Sar, D-Arg and D-Lys;
- R3 is selected from the group consisting of Val, Ala, Leu, Lys, norLeu, Ile, Gly, Pro, Aib, Acpc and Tyr;
- R4 is selected from the group consisting of Tyr, Tyr(PO3)2, Thr, Ser, Ala, homoSer and azaTyr;
- R5 is selected from the group consisting of Ile, Ala, Leu, norLeu, Val and Gly;
- R6 is selected from the group consisting of His, Arg or 6-NH2-Phe;
- R7 is selected from the group consisting of Pro or Ala;
- and
- R8 is selected from the group consisting of Phe, Phe(Br), Ile and Tyr, excluding sequences including R4 as a terminal Tyr group.
Dependencies are inferred from the claim text.