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US 6,747,007 B2Granted
Antimicrobial peptides and methods of use thereof
AssigneeThe University of British Columbia
InventorsRobert E. W. Hancock, Lijuan Zhang
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Abstract
A class of cationic, polyphemusin-like peptides having antimicrobial activity is provided. Examples of such peptides include FRWCFRVCYKGRCRYKCR (SEQ ID NO:3), RRWCFRVCYKGFCRYKCR (SEQ ID NO:4), and RRWCFRVCYRGRFCYRKCR (SEQ ID NO:11). Also provided are methods for inhibiting the growth of microbes such as bacteria, yeast and viruses utilizing the peptides of the invention. The peptides are particularly useful for inhibiting endotoxemia in a subject.
Claims1
An isolated peptide having antimicrobial activity and an amino acid sequence selected from the group consisting of:
- WCFZ5VCZ2RGZ3CRZ2KCRR (SEQ ID NO:14),
- Z2RWCFRVCYZ3GZ2CZ3Z5Z2CR (SEO ID NO:15),
- RRWCFZ5VCZ3RGZ4CYZ4Z4CRZ1 (SEQ ID NO:16),
- RZ5WCZ3Z2Z3CYRGFCZ3Z2Z5CR (SEQ ID NO:17),
- RRWCZ3RVCYZ5GFCYRKCR (SEQ ID NO:18), and
- RRWCFRVCYRGZ3FCYRKCR (SEQ ID NO:19);
- wherein Z1 is a basic amino acid residue or no amino acid residue;
- Z2 is a basic or aromatic residue, Z3 is a basic amino acid residue, Z4 is arginine, valine or alanine, and Z5 is an aromatic or aliphatic amino acid residue.
5 more elements
Dependencies are inferred from the claim text.