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US 6,747,004 B1Granted
Method for inducing growth and enhancing survival of nervous tissue
AssigneeNorth Shore-Long Island Jewish Research Institute
InventorSiamak Tabibzadeh
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AssigneeNorth Shore-Long Island Jewish Research Institute
InventorSiamak Tabibzadeh
Estimating the term…
The present invention provides a method of inducing growth or enhancing survival of nervous tissue comprising contacting the nervous tissue with an amount of ebaf effective to induce the growth or enhance the survival of the nervous tissue. The present invention also provides a method for treating a subject having damaged or degenerated nervous tissue comprising administering to the subject an amount of ebaf effective to treat the damaged or degenerated nervous tissue in the subject. The present invention further provides a method for treating a neurodegenerative disease in a subject comprising administering an amount of ebaf effective to treat the neurodegenerative disease. The present invention still further provides a method for preventing the onset or reducing the severity of damaged or degenerated nervous tissue in a subject comprising administering an amount of ebaf effective to prevent the onset or reduce the severity of the damaged or degenerated nervous tissue. Finally, the present invention provides a method for inducing growth or enhancing survival of nervous tissue comprising contacting the nervous tissue with a modulator of ebaf expression in an amount effective to induce or enhance expression of ebaf and induce the growth or enhance the survival of the nervous tissue.
A method for inducing proliferation of embryonic forebrain cells comprising contacting the embryonic forebrain cells in vitro with an amount of an endometrial bleeding associated factor (ebaf) protein effective to induce the proliferation of the forebrain cells, wherein the ebaf protein has the amino acid sequence set forth in SEQ ID NO:2.
A method for inducing growth or enhancing survival of forebrain cells, the method comprising contacting the forebrain cells in vitro with an amount of an endometrial bleeding associated factor (ebaf) protein effective to induce the growth or enhance the survival of the forebrain cells, wherein the ebaf protein has the amino acid sequence set forth in SEQ ID NO:2.
Dependencies are inferred from the claim text.