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US 6,747,002 B2Granted
Pharmacokinetic and pharmacodynamic modeling of erythropoietin administration
AssigneeOrtho-McNeil Pharmaceutical, Inc.
InventorsWing Cheung, David Gibson, Christine Cote, Els Vercammen
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Abstract
The present invention relates to systems and methods for obtaining optimized EPO dosage regimens for a desired pharmacodynamic/pharmacokinetic response. The system includes choosing one or more EPO dosage regimens, then using a PK/PD model to determine the pharmacodynamic/pharmacokinetic profile of one or more EPO dosage regimens, and finally selecting one of the EPO dosage regimens for administration to achieve the desired pharmacodynamic/pharmacodynamic response based on the EPO profile.
Claims30
A method comprising the step of:
- administering at least one EPO dose to a patient according to an EPO dosing regimen, wherein said regimen maintains at least a serum EPO concentration above a predose level for about 5 to about 30 days between EPO doses.
Dependencies are inferred from the claim text.