Preparation of factor XIIIa by gene manipulation
AssigneeAventis Behring GmbH
InventorsUlrich Grundmann, Egon Amann, Gerd Zettlmeissl
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Abstract
The cDNA which codes for factor XIIIa has been isolated using a cDNA bank from human placenta and probes constructed on the basis of the amino acid sequence of factor XIIIa peptide fragments. It is possible with this cDNA not only to obtain factor XIIIa by gene manipulation in high purity but also to prepare diagnostic aids which permit the analysis of genetic factor XIIIa defects. Furthermore, it is possible on the basis of the amino acid sequence to prepare antibodies which are suitable for diagnostic aids and antibody columns.
Claims9
An isolated DNA encoding factor XIIIa and having the sequence as set forth in FIG. 6.
An isolated DNA having a sequence which encodes the ainino acid sequence set forth in FIG. 6.
Dependencies are inferred from the claim text.