Nucleic acids encoding for endostatin protein
AssigneeChildren's Medical Center Corporation
InventorsMichael S. O′Reilly, M. Judah Folkman
Life of this patent
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Abstract
Nucleic acid sequences encoding for endostatin protein. Ribonucleic and deoxyribonucleic acid sequences that encode for endostatin protein are useful for gene therapy or recombinant expression for the treatment of angiogenesis-related diseases, specifically angiogenesis-dependent cancer.
Claims18
An isolated nucleic acid having a sequence that codes for a protein having an amino acid sequence of a fragment of a NC 1 C-terminal region of a collagen protein, wherein the protein inhibits angiogenesis.
A vector comprising the nucleic acid of claim 11, wherein the vector is capable of expressing the protein when present in a host cell.
A composition comprising an isolated nucleic acid having a sequence that codes for endostatin protein and angiostatin protein, wherein the endostatin protein has an amino acid sequence of a fragment of a NC1 C-terminal region of a collagen protein and is further characterized by its ability to specifically inhibit angiogenesis, and wherein the angiostatin protein has an amino acid sequence of a fragment of a kringle region of plasminogen and is further characterized by its ability to specifically inhibit angiogenesis.
Dependencies are inferred from the claim text.