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US 6,746,858 B1Granted
Murd protein and gene of Streptococcus pyogenes
AssigneeMerck & Co., Inc.
InventorsMohammed El-Sherbeini, Kenny Kin Wong
Life of this patent
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Abstract
This invention provides the murD gene of Streptococcus pyogenes. Purified and isolated MurD recombinant proteins are also provided. Nucleic acid sequences which encode functionally active MurD proteins are described. Assays for the identification of modulators of the expression of murD and inhibitors of the activity of MurD, are also provided.
Claims6
An isolated and purified polynucleotide fragment selected from the group consisting of:
- (a) a polynucleotide encoding a polypeptide having an amino acid sequence of SEQ ID NO:2, and
- (b) a polynucleotide which is complementary to the polynucleotide of (a).
A substantially purified polypeptide having an amino acid sequence of SEQ ID NO:2.
Dependencies are inferred from the claim text.