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US 6,746,856 B2Granted
Microbial conversion of bicyclic heteroaromatic compounds
AssigneePfizer Inc.
InventorsJames J. Cawley, John W. Wong
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Abstract
The present invention relates to processes for the microbial oxidation of bicyclic heteroaromatic compounds which comprise contacting these compounds with a microorganism, or a suitable mutant thereof, and incubating the resulting mixture under conditions sufficient to yield an amount of their respective carboxylic acids. The present processes optionally further comprise the isolation and purification of the product carboxylic acids.
Claims4
A process for the microbial oxidation of the compound of Formula II
- to the compound of Formula I
- which comprises:
- contacting said compound of Formula II with a microorganism capable of accomplishing the oxidation of the methyl group of the compound of Formula II to the carboxyl group of the compound of Formula I, and
- incubating the resultant mixture to yield an amount of the compound of Formula I.
1 more element
Dependencies are inferred from the claim text.