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US 6,746,842 B2Granted
Bio-molecular chip and manufacturing process thereof
AssigneeBioneer Corporation
InventorsHan-Oh Park, Han-Il Ko
Life of this patent
Estimating the term…
Abstract
The present invention relates to a bio-molecular microchip and manufacturing process thereof. More particularly, the present invention is directed to a bio-molecular microchip comprising a substrate; and an amine group-containing bio-molecule immobilized onto a glycidyl moiety-containing polyacrylamide gel via covalent bonds formed between the glycidyl moiety of the polyacryl amide gel and the amine group of the bio-molecule by epoxy ring-opening reaction.
Claims14
A process for manufacturing a bio-molecular chip, comprising:
- providing a substrate;
- applying a layer of glycidyl moiety-containing polyacrylamide gel on said substrate;
- and then
- applying a bio-molecule that contains an amine group onto said layer,
- wherein said glycidyl moiety-containing polyacrylamide gel is formed by copolymerizing glycidylmethacrylate, and acrylamide or polyacrylamide, and wherein said bio-molecule is immobilized on said layer of polyacrylamide gel via a covalent bond between the amine group of the bio-molecule and the glycidyl moiety of the polyacrylamide gel via an epoxy ring-opening reaction.
2 more elements
A bio-molecular chip comprising
- a substrate;
- a layer of a glycidyl moiety-containing polyacrylamide gel;
- and
- a biomolecule,
- wherein said biomolecule is immobilized onto said layer of glycidyl moiety-containing polyacrylamide gel via a covalent bond formed between the glycidyl moiety of said polyacrylamine gel and the amine group of the bio-molecule by epoxy ring-opening reaction.
2 more elements
Dependencies are inferred from the claim text.