Triterpene compositions and methods for use thereof
AssigneeResearch Development Foundation
InventorsCharles J. Arntzen, Jordan U. Gutterman
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Abstract
The invention provides novel saponin mixtures and compounds which are isolated from the species Acacia victoriae and methods for their use. These compounds may contain a triterpene moiety, such as acacic or oleanolic acid, to which oligosaccharides and monoterpenoid moieties are attached. The mixtures and compounds have properties related to the regulation of apoptosis and cytotoxicity of cells and exhibit potent anti-tumor effects against a variety of tumor cells.
Claims15
A method of inhibiting deleterious effects of ultraviolet light exposure to skin, comprising applying a safe and effective amount of a topical composition comprising a plant extract from Acacia victoriae wherein the plant extract comprises a triterpene moiety attached to a monoterpene moiety having the molecular formula:
- or a pharmaceutical formulation thereof, wherein
- a) R1 and R2 are selected from the group consisting of hydrogen, C1-C5 alkyl, and an oligosaceharide;
- b) R3 is selected from the group consisting of hydrogen, hydroxyl, C1-C5 alkyl, C1-C5 alkylene, C1-C5 alkyl carbonyl, a sugar, and a monoterpene group;
- and
- c) the formula further comprises R4, wherein R4 is selected from the group consisting of hydrogen, hydroxyl, C1-C5 alkyl, C1-C5 alkylene, C1-C5 alkyl carbonyl, a sugar, C1-C5 alkyl ester, and a monoterpene group, and wherein R4 may be attached to the triterpene moiety or the monoterpene moiety.
Dependencies are inferred from the claim text.