Process for producing composite preparation containing nucleic acid
AssigneeNippon Shinyaku Co., Ltd.
InventorsKatsuhiro Sugihara, Junzo Seki, Kazuko Hirabayashi
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Abstract
A method for producing a composition including a nucleic-acid-containing complex is characterized in that two single strand nucleic acid polymers which can at least partly form double strands are separately mixed, in a single strand form, with a cationic carrier or with source materials for the cationic carrier before the cationic carrier is formed. The resulting mixture is then dispersed in water during the production process of the nucleic-acid-containing complex.
Claims12
A composition containing a nucleic-acid-containing complex produced by mixing two single strand nucleic acid polymers which can at least partly form double strands, in a single strand form, with a cationic carrier or with source materials for the cationic carrier before the cationic carrier is formed in an aqueous solution, and dispersing the mixture in an aqueous solution during the production process of the nucleic acid containing complex, wherein the complex comprises a cationic carrier and two single strand nucleic acid polymers which can at least partly form double strands, and wherein an average complex particle size is, no more than about 0.2 μm in diameter while in a solution state, or a lyophilized composition thereof.
A composition containing a nucleic-acid-containing complex produced by mixing two single strand nucleic acid polymers which can at least partly form double strands, in a single strand form, with a cationic carrier or with source materials for the cationic carrier before the cationic carrier is formed in an aqueous solution, and dispersing the mixture in an aqueous solution during the production process of the nucleic acid containing complex, wherein the complex comprises a cationic carrier and two single strand nucleic acid polymers which can at least partly form double strands, and wherein the complex particles of the composition can pass through a 0.2 μm sterilizing filtration membrane filter while in a solution state, or a lyophilized composition thereof.
Dependencies are inferred from the claim text.