Cytostatin II
AssigneeHuman Genome Sciences, Inc.
InventorsJian Ni, Guo-Liang Yu, Reiner L. Gentz
Life of this patent
Estimating the term…
Abstract
The invention relates to cytostatin II growth modulatory polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
Claims58
An isolated protein comprising a polypeptide having an amino acid sequence of amino acids 1 to 132 of SEQ ID NO:2.
An isolated protein comprising a polypeptide having the amino acid sequence of the full-length polypeptide encoded by the cDNA contained in ATCC Deposit No. 97287.
An isolated protein comprising a polypeptide having an amino acid sequence selected from the group consisting of:
- (a) a polypeptide of amino acids 1 to 132 as set forth in SEQ ID NO:2 which inhibits cellular growth, in which 1 to 5 amino acid residues are substituted, deleted or added in any combination;
- and
- (b) a polypeptide amino acids 1 to 132 as set forth in SEQ ID NQ:2 which inhibits cellular growth, in which 5 to 10 amino acid residues are substituted, deleted or added in any combination.
An isolated protein comprising a polypeptide having an amino acid sequence selected from the group consisting of:
- (a) the amino acid sequence of the full-length polypeptide encoded by the cDNA contained in ATCC Deposit No. 97287 which inhibits cellular growth, in which 1 to 5 amino acid residues are substituted, deleted or added in any combination;
- and
- (b) the amino acid sequence of the full-length polypeptide encoded by the cDNA contained in ATCC Deposit No. 97287 which inhibits cellular growth, in which 5 to 10 amino acid residues are substituted, deleted or added in any combination.
An isolated protein consisting of a fragment of at least 50 contiguous amino acid residues of SEQ ID NQ:2.
An isolated protein consisting of a fragment of at least 50 contiguous amino acid residues of the full-length polypeptide encoded by the cDNA contained in ATCC Deposit No. 97287.
An isolated protein comprising a polypeptide sequence which is at least 90% identical to amino acid residues 1 to 132 of SEQ ID NO:2, wherein said isolated protein is capable of inhibiting cellular growth.
An isolated protein comprising a polypeptide sequence which is at least 90% identical to the polypeptide encoded by the cDNA contained in ATCC Deposit No. 97287, wherein said isolated protein is capable of inhibiting cellular growth.
An isolated protein comprising a polypeptide sequence which is at least 90% identical to amino acid residues 1 to 132 of SEQ ID NO:2, wherein said isolated protein is capable of stimulating cellular differentiation.
An isolated protein comprising a polypeptide sequence which is at least 90% identical to the polypeptide encoded by the cDNA contained in ATCC Deposit No. 97287, wherein said isolated protein is capable of stimulating cellular differentiation.
Dependencies are inferred from the claim text.