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US 6,746,671 B2Granted
Use of a cytokine-producing lactococcus strain to treat colitis
AssigneeVlaams Interuniversitair Instituut Voor Biotechnologie VZW
InventorsLothar Steidler, Erik R. Remaut, Walter Fiers
Life of this patent
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Abstract
An administration strategy for the delivery at the intestinal mucosa of cytokines or cytokine antagonists, preferably of acid sensitive anti-inflammatory agents, for example, IL10 and/or soluble TNF receptor via the oral route. Preferably, inoculation occurs along with a suspension of recombinant Lactococcus lactis cells, which had been engineered to produce the respective proteins.
Claims14
A method of treating inflammatory bowel disease in a mammal, said method comprising:
- administering a medicament to a mammal with inflammatory bowel disease comprising an amount of a cytokine- or cytokine antagonist-producing genetically modified non-invasive Gram-positive bacterial strain, wherein the administration of said medicament results in reduction of intestinal mucosal inflammation by at least 50%,
- wherein said cytokine or cytokine-antagonist is selected from the group consisting of IL-10, a soluble TNF receptor, a TNF antagonist, an IL-12 derived homodimer, and EBV BCRF1.
Dependencies are inferred from the claim text.