Apo-2 ligand
AssigneeGenentech, Inc.
InventorAvi J. Ashkenazi
Life of this patent
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Abstract
A novel cytokine, designated Apo-2 ligand, which induces mammalian cell apoptosis is provided. The Apo-2 ligand is believed to be a member of the TNF cytokine family. Compositions including Apo-2 ligand chimeras, nucleic acid encoding Apo-2 ligand, and antibodies to Apo-2 ligand are also provided. Methods of using Apo-2 ligand to induce apoptosis and to treat pathological conditions such as cancer, are further provided.
Claims9
A method of treating a mammal having prostate cancer, comprising administering to the mammal Apo-2 ligand polypeptide in an amount effective to induce cell death in the mammal's prostate cancer cells, wherein said Apo-2 ligand polypeptide is selected from the group consisting of:
- (a) a polypeptide comprising amino acid residues 114-281 of FIG. 1A (SEQ ID NO:1);
- (b) a polypeptide consisting of amino acid residues 114-281 of FIG. 1A (SEQ ID NO:1);
- (c) a polypeptide consisting of amino acid residues 1-281 of FIG. 1A (SEQ ID NO:1);
- (d) a polypeptide which is a fragment of (a), (b) or (c).
Dependencies are inferred from the claim text.