Methods for micronization of hydrophobic drugs

A method for micronizing a hydrophobic agent, comprising:

• dissolving a hydrophobic agent in an effective amount of a first solvent, wherein the first solvent is free of polymer, wherein the hydrophobic agent and the solvent form a mixture having a continuous phase,
• introducing a second solvent into the mixture, and
• introducing an aqueous solution into the mixture wherein the aqueous solution causes precipitation of the hydrophobic agent to produce a composition of micronized hydrophobic agent having an average particle size of 1 micron or less.