Ammonium ionophore, an ammonium ion selective matrix, an ammonium ion-selective sensor, and a method for detecting ammonium ions in a fluid sample
AssigneesBayer Aktiengesellschaft, Worcester Polytechnic Institute
InventorsJohn S. Benco, W. Grant McGimpsey
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Abstract
An ammonium selective ionophore for use in ion selective electrodes.
Claims12
A compound, having the structure:
A method of making a compound having the structure:
- comprising the steps of:
- (a) obtaining a compound having the structure:
- (b) obtaining a compound having the structure:
- (c) synthesizing an acyclic depsipeptide from the compounds obtained in step (a) and step (b);
- and
- (d) synthesizing the compound having the structure:
- from the acyclic depsipeptide of step (c).
An ammonium ion selective matrix, comprising:
- (a) an ionophore having the structure:
- wherein
- (i) wherein R is a chemical group selected from the set consisting of hydrogen and alkyl, alkoxyalkyl, alkoxyacyl, alkylamino, alkylnitroso, alkylcyano, alkylthio, alkylsulfinyl, alkylsulfonyl, alkenyl, alkoxyalkenyl, alkenylacyl, alkenylamino, alkenylnitroso, alkenylcyano, alkenylthio, alkenylsulfinyl, alkylsulfonyl, alkynyl, alkoxyalkynyl, alkynylacyl, alkynylamino, alkynylnitroso, alkynylcyano, alkynylthio, alkynylsulfinyl, and alkynylsulfonyl and substituted or unsubstituted aryl groups with or with out heteroatoms, and
- (ii) R′ is either nitrogen or oxygen;
- and
- (b) an ammonium ion permeable matrix material in which the ionophore is situated, wherein the matrix is adapted for use in an ion selective electrode.
A method for detecting the presence of ammonium ions in a fluid sample, comprising the steps of:
- (a) obtaining a matrix comprising an ionophore having the structure:
- wherein
- (i) wherein R is a chemical group selected from the set consisting of hydrogen and alkyl, alkoxyalkyl, alkoxyacyl, alkylamino, alkylnitroso, alkylcyano, alkylthio, alkylsulfinyl, alkylsulfonyl, alkenyl, alkoxyalkenyl, alkenylacyl, alkenylamino, alkenylnitroso, alkenylcyano, alkenylthio, alkenylsulfinyl, alkylsulfonyl, alkynyl, alkoxyalkynyl, alkynylacyl, alkynylamino, alkynylnitroso, alkynylcyano, alkynylthio, alkynylsulfinyl, and alkynylsulfonyl and substituted or unsubstituted aryl groups, with or without heteroatoms group, and
- (ii) R′ is either nitrogen or oxygen;
- wherein the matrix is adapted for use in an ion selective electrode;
- (b) connecting the matrix with a sensing instrument;
- (c) providing an electrical signal, potential or current, to the sensing instrument through the matrix;
- (d) contacting the fluid sample with the matrix;
- and
- (e) measuring an electrical signal provided by the sensing instrument;
- wherein the electrical signal can be correlated with the activity of ammonium ions in the fluid sample.
An ammonium ion-selective sensor, comprising an ammonium ion permeable matrix material, wherein the matrix is adapted for use in an ion selective electrode, wherein the matrix comprises an ionophore having the structure:
- wherein
- (a) R is a chemical group selected from the set consisting of hydrogen and alkyl, alkoxyalkyl, alkoxyacyl, alkylamino, alkylnitroso, alkylcyano, alkylthio, alkylsulfinyl, alkylsulfonyl, alkenyl, alkoxyalkenyl, alkenylacyl, alkenylamino, alkenylnitroso, alkenylcyano, alkenylthio, alkenylsulfinyl, alkylsulfonyl, alkynyl, alkoxyalkynyl, alkynylacyl, alkynylamino, alkynylnitroso, alkynylcyano, alkynylthio, alkynylsulfinyl, and alkynylsulfonyl and substituted or unsubstituted aryl groups, with or without heteroatoms, and
- (b) R′ is either nitrogen or oxygen.
An ammonium ion-selective sensor, comprising an ammonium ion permeable matrix material comprising an ionophore having the structure:
Dependencies are inferred from the claim text.