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US 6,743,626 B2Granted
Artificial salivary gland
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsBruce J. Baum, Kenneth M. Yamada, Edna Cukierman, David Mooney
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Abstract
The present invention generally relates to the field of oral prosthetics and tissue engineering. More specifically, a novel, artificial fluid secreting prosthesis for non-invasive insertion is disclosed. Further, methods of use of the foregoing are provided.
Claims1
An article of manufacture comprising:
- a) a water and salt permeable, porous biodegradable blind end tube having an interior surface,
- b) matrix components coating said interior surface capable of promoting the formation of a polarized monolayer of salivary gland epithelial cells, and
- c) a polarized monolayer of salivary gland epithelial cells, said salivary gland epithelial cells disposed on said interior surface and having a phenotype in which said salivary gland epithelial cells express or are transduced to express a water channel protein and ion transport protein so that water and salt is secreted unidirectionally.
Dependencies are inferred from the claim text.