Low temperature coatings
AssigneeBTG International Limited
InventorsJohn Michael Newton, Chuei Wuei Leong
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Abstract
A method of coating an active material is provided. The method comprises contacting an active material with a film-forming composition comprising an aqueous dispersion of an amylose-alcohol complex, an insoluble film-forming polymer and a plasticiser at a temperature of less than 60° C. The method finds particular application in the preparation of dosage forms comprising active materials that are unstable at temperatures in excess of 60° C. The compositions prepared in accordance with the method can be used to deliver an active material to the colon.
Claims17
A method of coating an active material or a dosage form containing an active material which coating retains the active material during passage through the gastro-intestinal tract and releases it in the colon, said method comprising contacting the active material or dosage form containing it at a temperature of less than 60° C. with a film-forming composition comprising an aqueous dispersion of an amylose-alcohol complex, an insoluble film-forming polymer and a plasticiser, coating being carried out at a temperature less than 60° C.
A method of coating a temperature sensitive active material or a dosage form containing such an active material which coating retains the active material during passage through the gastro-intestinal tract and releases it in the colon, said method comprising contacting the active material or dosage form containing it at a temperature less than 60° C. with a film-forming composition comprising an aqueous dispersion of an amylose-alcohol complex, an insoluble film-forming polymer and a plasticiser, coating being carried out at a temperature which is less than 60° C. and at which the integrity of the active material is maintained during the coating step.
Dependencies are inferred from the claim text.