US 6,743,433 B2Granted

Treatment of acne using alkanolamine compositions

OwnerNicholas V. Perriconeinventor

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Abstract

Acne is treated or prevented by the topical application of compositions containing an alkanolamine such as dimethylaminoethanol, tyrosine, and a sulfur ingredient such as lipoic acid or glutathione. Adjunct ingredients such as fatty acid esters of ascorbic acid, e.g., ascorbyl palmitate and α-hydroxy acids may be included in the formulations. Compositions of the invention may be used alone, or, in many preferable embodiments, in combination with conventional acne medications such as anti-acne products containing salicylic acid, benzoyl peroxide, or a retinoid. In these embodiments, alkanolamine compositions of the invention are applied to affected skin areas first, and then a conventional acne medication is applied. This maximizes the efficacy of the treatment while minimizing skin irritation caused by conventional medications.

Claims4

Dependent claims

A method for treating acne comprising

A) first applying to affected skin areas a composition comprising
1) an effective amount of an alkanolamine selected from the group consisting of ethylamino-ethanol, methylaminoethanol, dimethylaminoethanol, isopropanolamine, triethanolamine, isopropanoldimethylamine, ethylethanolamine, 2-butanolamine, choline, serine, and mixtures thereof;
2) tyrosine;
and
3) an effective amount of a sulfur ingredient selected from the group consisting of liquid acid, glutathione, sulfur, a combination of sulfur and resorcinol, a combination of sulfur and resorcinol monoacetate, sulfacetamide, and mixtures thereof;
and
B) then applying to the same areas a composition comprising an effective amount of a conventional acne medication containing an active anti-acne ingredient selected from the group consisting of benzoyl peroxide, lauroyl peroxide, carbamide peroxide, ethanol, phenoxy ethanol, propanol, phenoxy propanol, resorcinol, ethyl acetate, salicylic acid, azelaic acid, fumic acid, dehydroacetie acid, pyruvic acid, urea, cetyl betaine, scymnol sulfate, chocolate, deoxycholate, adalpalene, tretinoin, tazarotene, erythromycin, lincomycin, clindamycin, tetracycline and meclocycline.

4 more elements

Dependencies are inferred from the claim text.

Facts

Application: 10/085,864Filed 27 Feb 2002 · continuation in part
Priority: 6 Jul 2001
Published: US 2003/0017177 A130 Jan 2003
Granted: 1 Jun 2004
Term ends: Not estimatedThe source records don’t support an estimate.

Classification20 codes

A61K 8/0208
Characterised by special physical form: tissues; Wipes; Patches
A61K 8/38
Containing oxygen: percompounds, e.g. peracids
A61K 8/41
Containing nitrogen: amines
A61K 8/44
Containing nitrogen: aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated…