Use of adeno-associated viruses for decreasing the radiotherapy-induced or chemotherapy- induced resistance in cancer patients
AssigneeDeutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts
InventorsMangus Von Knebel-Doeberitz, Petra Klein-Bauernschmitt, Harald Zur Hausen, Jörg Schlehofer
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Abstract
The invention relates to the use of adeno-associated viruses for decreasing the radiotherapy-induced or chemotherapy-induced resistance in patients who suffer from a cancer which is to be treated by radiotherapy or chemotherapy.
Claims9
A method for lowering chemotherapy resistance in a patient being treated with a chemotherapeutic agent for a small cell lung or pancreatic cancer, the method comprising:
- administering to the patient an effective amount of AAV-2 to lower the chemotherapy resistance to the chemotherapeutic agent, in combination with administering a chemotherapeutic agent, wherein the effective amount of AAV-2 is administered intratumorally;
- and
- determining if the chemotherapy resistance to the chemotherapeutic agent is lowered.
A pharmaceutical composition containing a chemotherapeutic agent and an effective dose of AAV-2 to lower resistance of tumor cells to the chemotherapeutic agent in patients suffering from a cancer selected from the group consisting of pancreatic carcinoma, and small cell lung carcinoma, wherein the pharmaceutical composition is administered intratumorally.
A method for enhancing chemosensitivity of cancer tumor cells to a chemotherapeutic agent to reduce tumor growth, the method comprising:
- administering a sufficient amount of AAV-2 intratumorally to enhance chemosensitivity of the cancer tumor cells to the chemotherapeutic agent, in combination with administering the chemotherapeutic agent to the cancer cells, and
- determining if tumor growth is reduced, whereby a reduction in tumor growth indicates the chemosensitivity of cancer tumor cells is enhanced and wherein the tumor cells are selected from small cell lung cancer or pancreatic cancer.
Dependencies are inferred from the claim text.