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US 6,743,417 B2Granted
Method of treating onychomycosis with urea and an antioxidant
AssigneeBradley Pharmaceuticals, Inc.
InventorsBradley P. Glassman, Dileep Bhagwat, Daniel Glassman
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Abstract
A method of treating onychomycosis is described which includes administration of a topical formulation containing an effective amount of urea and an antioxidant to an infected area around a nail of a patient.
Claims22
A method of treating onychomycosis comprising administering to the nail area of a patient in need thereof a composition comprising:
- about 10 to about 40 wt-% urea;
- about 0.1 to about 20 wt-% of an antioxidant;
- about 5.5 to about 20 wt-% petrolatum or a synthetic or semi-synthetic hydrocarbon, or a semi-solid mixture thereof;
- about 10 to about 20 wt-% of a liquid petrolatum or a synthetic or semi-synthetic oleaginous liquid fraction, or a mixture thereof;
- about 0.25 to about 2 wt-% of a C16-18 aliphatic straight or branched chain fatty alcohol or fatty acid, or a mixture thereof;
- about 1 to about 5 wt-% propylene glycol;
- about 1 to about 3 wt-% glyceryl stearate;
- about 0.01 to about 0.5 wt-% xanthan gum;
- and
- the balance being water.
7 more elements
A method of treating onychomycosis comprising administering to the nail area of a patient in need thereof a composition comprising:
- about 10 to about 40 wt-% urea;
- about 0.1 to about 20 wt-% of an antioxidant;
- about 5.5 to about 20 wt-% petrolatum or a synthetic or semi-synthetic hydrocarbon, or a semi-solid mixture thereof;
- about 10 to about 20 wt-% of a liquid petrolatum or a synthetic or semi-synthetic oleaginous liquid fraction, or a mixture thereof;
- about 0.25 to about 2 wt-% of a C16-18 aliphatic straight or branched chain fatty alcohol or fatty acid, or a mixture thereof;
- about 1 to about 5 wt-% propylene glycol;
- about 1 to about 3 wt-% glyceryl stearate;
- about 0.01 to about 0.5 wt-% xanthan gum;
- about 0.05 to about 30 wt-% of a mixture of a carbomer and triethanolamine;
- and
- the balance being water.
8 more elements
A method of treating onychomycosis, comprising:
- administering to the nail area of a patient consisting essentially of urea as the active antifungal ingredient, an antioxidant, and one more dermatologically acceptable excipients, wherein the urea is present in an amount therapeutically effective for treating onychomycosis.
Dependencies are inferred from the claim text.