High throughput high performance chromatography system
AssigneeJohnson & Johnson
InventorsAdam M. Fermier, Elias H. Hochman, Norberto A. Guzman, Stephen Scypinski
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Abstract
A high throughput high performance chromatography system operating at a high mixing pressure including a plurality of pressurized solvent reservoirs, e.g. pumps, each maintaining an associated solvent at a substantially constant pressure. A plurality of flow control valves are connected downstream or upstream of the reservoirs for controlling the flow rate of the solvent into the respective columns. The number of reservoirs equals the number of solvents. Accordingly, the system reduces the number of pumps required thereby saving money and space. Furthermore, the system increases sample throughput, accelerates method development and minimizes organic waste.
Claims23
A high throughput high performance chromatography system operating at a high mixing pressure, comprising:
- at least one pressurized solvent reservoir maintaining an associated solvent at a substantially constant pressure, wherein the number of solvent reservoirs equals the number of solvents;
- a plurality of flow control valves connected downstream of and in fluid communication with each of said reservoirs;
- a plurality of columns connected downstream of said at least one reservoir, said valves controlling the flow rate of the solvent into the respective columns;
- and
- a plurality of injectors in communication with said plurality of columns such that one injector introduces one sample into one column, the injectors being operable such that multiple samples can be simultaneously introduced into multiple columns and a sample gradient introduced to each column is controllable independent from gradients introduced to other columns.
A high throughput high performance chromatography system operating at a high mixing pressure, comprising:
- a plurality of pressurized solvents reservoirs maintaining associated solvents each at substantially constant pressure, the number of solvent reservoirs equaling the number of solvents;
- a plurality of flow control valves connected downstream of each reservoir,
- a plurality of columns connected downstream of the plurality of the valves, each valve controlling the flow rate of one solvent into one column, wherein fluid communication is permitted between each reservoir and a plurality of columns with one valve being disposed within the connection between each reservoir and each column;
- and
- a plurality of injectors in communication with said plurality of columns such that one injector introduces one sample into one column, the injectors being operable such that multiple samples can be simultaneously introduced into multiple columns and a sample gradient introduced to each column is controllable independent from gradients introduced to other columns.
Dependencies are inferred from the claim text.