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US 6,743,253 B2Granted
Polyurethane-sealed biocompatible device and method for its preparation
AssigneesBioMod Surfaces, Beth Israel Deaconess Medical Center, Inc.
InventorsMatthew D. Phaneuf, Donald J. Dempsey, William C. Quist, Frank W. Logerfo
Life of this patent
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Abstract
Provided is a biocompatible device which has been coated or sealed with a polyether or polyether/carbonate based urethane polymer that contains functional groups (e.g. carboxylic acid groups) which are capable of serving as anchor sites for protein binding.
Claims19
A biocompatible device adapted for therapeutic use within the body of a mammal, said device comprising:
- (a) a polymeric base;
- and
- (b) a surface layer coating said polymeric base, said surface layer coating comprising a polyether or polyether/carbonate based urethane polymer having carboxylic acid groups serving as anchor sites prepared by a method comprising the steps of:
- (i) forming a diisocyanate terminated prepolymer based on (i) a polyether glycol or polyether/carbonate glycol having a molecular weight between about 200 to 3,000 Da and (ii) a diisocyanate having the general structure OCN—R′—NCO, wherein R′ is a hydrocarbon;
- and
- (ii) chain extending said prepolymer using a dihydroxy carboxylic acid.
3 more elements
Dependencies are inferred from the claim text.