Sugar derivatives of hydromorphone, dihydromorphine and dihydromorphine, compositions thereof and uses for treating or preventing pain
AssigneeEuro-Celtique S.A.
InventorsFeng Gao, Jahanara Miotto
Life of this patent
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Abstract
Glucoside and glucuronide derivatives of hydromorphone, dihydromorphine, and dihydroisomorphine and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising a glucoside or glucuronide derivative of hydromorphone, dihydromorphine, or dihydroisomorphine or a pharmaceutically acceptable salt thereof; and methods for treating or preventing pain in a patient comprising administering to a patient in need thereof a glucoside or glucuronide derivative of hydromorphone, dihydromorphine, or dihydroisomorphine or a pharmaceutically acceptable salt thereof are disclosed.
Claims51
Nordihydromorphine-3-glucuronide or a pharmaceutically acceptable salt thereof.
Nordihydroisomorphine-3-glucuronide or a pharmaceutically acceptable salt thereof.
Norhydromorphone-3-glucuronide or a pharmaceutically acceptable salt thereof.
The 3-O-glucosylhydromorphone or pharmaceutically acceptable salt thereof in isolated and purified form.
The 3-O-glucosyldihydroisomorphine or pharmaceutically acceptable salt thereof in isolated and purified form.
The 6-O-glucosyldihydroisomorphine or pharmaceutically acceptable salt thereof in isolated and purified form.
The 3-O-glucosyldihydromorphine or pharmaceutically acceptable salt thereof in isolated and purified form.
The 6-O-glucosyldihydromorphine or pharmaceutically acceptable salt thereof in isolated and purified form.
A method for treating pain in a patient, comprising administering to a patient in need thereof an effective amount of 3-0-glucosylhydromorphone or pharmaceutically acceptable salt thereof.
A method for treating pain in a patient, comprising administering to a patient in need thereof an effective amount of 3-0-glucosyldihydroisomorphine or pharmaceutically acceptable salt thereof.
A method for treating pain in a patient, comprising administering to a patient in need thereof an effective amount of 6-0-glucosyldihydroisomorphine or pharmaceutically acceptable salt thereof.
A method for treating pain in a patient, comprising administering to a patient in need thereof an effective amount of 3-0-glucosyldihydromorphine or pharmaceutically acceptable salt thereof.
A method for treating pain in a patient, comprising administering to a patient in need thereof an effective amount of 6-0-glucosyldihydromorphine or pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.