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US 6,737,522 B2Granted
Chicken interleukin-15 and uses thereof
AssigneeWayne State University
InventorsRoy S. Sundick, Lily A. Jones, David I. Smith
Life of this patent
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Abstract
The present invention pertains to isolated DNA encoding avian interleukin-15 and to purified interleukin-15 polypeptides.
Claims27
An isolated nucleic acid which:
- (a) comprises a nucleic acid sequence having at least 70% sequence homology, determined by a BLAST algorithm, to the sequence set forth in nucleotides 87-449 of SEQ ID NO:1;
- and
- (b) encodes a polypeptide capable of stimulating thymidine incorporation in mitogen activated avian T-cells.
An isolated nucleic acid which:
- (a) hybridizes to the full length of a nucleic acid having the complementary sequence of nucleotides 87-449 in SEQ ID NO:1 under conditions comprising (i) hybridization in 6×SSC and 0.5% SDS, and (ii) washing at 68° C. in 0.1×SSC and 0.5% SDS;
- and
- (b) encodes a polypeptide capable of stimulating thymidine incorporation in mitogen activated avian T-cells.
An isolated nucleic acid which:
- (a) hybridizes to the full length of a nucleic acid having the complementary sequence of nucleotides 87-449 in SEQ ID NO:1 under conditions comprising (i) hybridization in 6×SSC and 0.5% SDS, and (ii) washing at room temperature in 2×SSC and 0.5% SDS;
- and
- (b) encodes a polypeptide capable of stimulating thymidine incorporation in mitogen activated avian T-cells.
An isolated nucleic acid having an open reading frame that encodes a polypeptide comprising the sequence of amino acid residues 23-143 set forth in SEQ ID NO:2 (FIG. 2).
Dependencies are inferred from the claim text.