Nitric oxide-modified linear poly(ethylenimine) fibers and uses thereof
AssigneeThe University of Akron
InventorsDaniel J. Smith, Darrell H. Reneker
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Abstract
A novel coating for medical devices provides nitric oxide delivery using nanofibers of linear poly(ethylenimine)diazeniumdiolate. Linear poly(ethylenimine)diazeniumdiolate releases nitric oxide (NO) in a controlled manner to tissues and organs to aid the healing process and to prevent injury to tissues at risk of injury. Electrospun nano-fibers of linear poly(ethylenimine) diazeniumdiolate deliver therapeutic levels of NO to the tissues surrounding a medical device while minimizing the alteration of the properties of the device. A nanofiber coating, because of the small size and large surface area per unit mass of the nanofibers, provides a much larger surface area per unit mass while minimizing changes in other properties of the device.
Claims12
A medical device comprising at least one nanofiber of a linear poly(ethylenimine) diazeniumdiolate, said at least one nanofiber forming a coating layer on the device.
A method of using a medical device comprising the steps of:
- a) providing a medical device which is coated with at least one nanofiber of linear poly(ethylenimine) diazeniumdiolate;
- b) using the medical device in the medical treatment of a mammal.
Dependencies are inferred from the claim text.