Cis-imidazolines

At least one compound selected from a compound of formula I

• or pharmaceutically acceptable salts or esters thereof, wherein
• R is —C═OR1,
• wherein R1 is selected from C1-C4 alkyl, —C═CHCOOH, —NHCH2CH2R2, —N(CH2CH2OH)CH2CH2OH, —N(CH3)CH2CH2NCH3, —N(CH3)CH2CH2N(CH3)CH3, saturated 4-, 5- and 6-membered rings, and saturated and unsaturated 5- and 6-membered rings containing at least one hetero atom wherein the hetero atom is selected from S, N and O and being optionally substituted with a group selected from lower alkyl, —C═O—R5, —OH, lower alkyl substituted with hydroxy, lower alkyl substituted with —NH2, N-lower alkyl, —SO2CH3, ═O, —CH2C═OCH3, and 5- and 6-membered saturated rings containing at least one hetero atom selected from S, N and O,
• wherein R5 is selected from H, lower alkyl, —NH2, —N-lower alkyl, lower alkyl substituted with hydroxy, and lower alkyl substituted with NH2,
• wherein R2 is selected from —N(CH3)CH3, —NHCH2CH2NH2, —NH2, morpholinyl and piperazinyl,
• X1, X2 and X3 are independently selected from —OH, C1-C2 alkyl, C1-C5 alkoxy, —Cl, —Br, —F, —CH2OCH3, and —CH2OCH2CH3,
• or one of X1, X2 or X3 is H and the other two are independently selected from hydroxy, lower alkyl, lower alkoxy, Cl, Br, F, —CF3, —CH2OCH3, —CH2OCH2CH3, —OCH2CH2R3, —OCH2CF3, and —OR4,
• or one of X1, X2 or X3 is H and the other two taken together with the two carbon atoms and the bonds between them from the benzene ring to which they are substituted form a 5- or 6-membered saturated ring that contains at least one hetero atom selected from S, N, and O, wherein R3 is selected from —F, —OCH3, —N(CH3)CH3, unsaturated 5- and 6-membered rings containing at least one hetero atom wherein the hetero atom is selected from S, N and O,
• wherein R4 is a 3- to 5-membered saturated ring and
• Y1 and Y2 are each independently selected from —Cl, —Br, —NO2, —C≡N, and —C≡CH.