Purine derivatives and medicaments comprising the same as active ingredient
AssigneeMitsubishi Chemical Corporation
InventorsToshihiko Tanaka, Eiichirou Iwashita, Akiko Tarao, Akira Amenomori, Yuya Ono
Life of this patent
Estimating the term…
Abstract
Purine derivatives represented by the following formula and salts thereof: wherein R1 represents a C1-C4 alkyl group or difluoromethyl group; R2 represents tetrahydrofuranyl group, a C1-C7 alkyl group and the like; X represents hydrogen atom, a halogen atom or nitro group; and A represents a group represented by the following formula: wherein R3 represents hydrogen atom, a halogen atom and the like; R4 and R5 represent hydrogen atom, a halogen atom, a C1-C4 alkyl group, a C1-C4 alkoxyl group and the like, which are useful as active ingredients of medicaments such as antiasthmatic agents.
Claims24
A purine derivative represented by the following formula (I), a salt thereof, or an N-oxide thereof, or a hydrate thereof or a solvate thereof:
- wherein R1 represents a C1-C4 alkyl group or difluoromethyl group;
- R2 represents tetrahydrofuranyl group, a C1-C7 alkyl group, a C1-C7 haloalkyl group, a C2-C7 alkenyl group, bicyclo[2,2,1]hept-2-yl group, or a C3-C8 cycloalkyl group;
- X represents hydrogen atom, a halogen atom, or nitro group;
- and A represents a group represented by the following formula:
- wherein R3 represents hydrogen atom, a halogen atom, hydroxyl group, a C1-C4 alkyl group, a C1-C4 alkoxyl group, amino group, a C1-C4 alkylamino group, or a C2-C8 dialkylamino group;
- R4 and R5 each independently represent hydrogen atom, a halogen atom, a C1-C4 alkyl group, a C1-C4 alkoxyl group, amino group, a C1-C4 alkylamino group, pyrrolidinyl group, morpholino group, a C2-C8 dialkylamino group, or a group represented by —Y—(CH2)n—B {Y represents —O—, —S—, —NHCO—, or —N(R6)— (R6 represents hydrogen atom or a C1-C4 alkyl group), n represents an integer of from 0 to 4, and B represents a phenyl group, a naphthyl group, or a heterocyclic residue, each of which may be substituted},
- provided that either R4 or R5 represents —Y—(CH2)n—B {Y represents —O—, —S—, —NHCO—, or —N(R6)— (R6 represents hydrogen atom or a C1-C4 alkyl group)} when X represents hydrogen atom, and
- (i) n represents an integer of from 0 to 4, and B represents a phenyl group, a naphthyl group, or a heterocyclic residue, each of which may be substituted when Y represents —O—, —S—, or —NHCO—, or
- (ii) n represents an integer of from 1 to 4, and B represents a heterocyclic residue when Y represents —N(R6)—.
2-Chloro-9-[(3-cyclopentyloxy-4-methoxy)benzyl]-6,8-dimethylpurine or a salt thereof, or a hydrate thereof or a solvate thereof.
9-[(3-Cyclopentyloxy-4-methoxy)benzyl]-6,8-dimethyl-2-methoxypurine or a salt thereof, or a hydrate thereof or a solvate thereof.
9-[(3-Cyclopentyloxy-4-methoxy)benzyl]-6,8-dimethyl-2-(pyridazinylmethyloxy)purine or a salt thereof, or a hydrate thereof or a solvate thereof.
9-[(3-Cyclopentyloxy-4-methoxy)benzyl]-6,8-dimethyl-2-[4-pyridylmethyl-oxy]purine or a salt thereof, or a hydrate thereof or a solvate thereof.
4-[[9-[(3-Cyclopentyloxy-4-methoxy)benzyl]-6,8-dimethylpurin]-2-yl-oxy-methyl]pyridine N-oxide or a salt thereof, or a hydrate thereof or a solvate thereof.
9-[(3-Cyclopentyloxy-4-methoxy)benzyl]-6,8-dimethyl-2-[2-(4-pyridyl)-ethyloxy]purine or a salt thereof, or a hydrate thereof or a solvate thereof.
4-[[9-[(3-Cyclopentyloxy-4-methoxy)benzyl]-6,8-dimethylpurin]-2-yl-2-oxy-ethyl]pyridine N-oxide or a salt thereof, or a hydrate thereof or a solvate thereof.
9-[(3-Cyclopentyloxy-4-methoxy)benzyl]-6-methylamino-2-(3-pyridazinyl-methyloxy)purine or a salt thereof, or a hydrate or a solvate thereof.
9-[(3-Cyclopentyloxy-4-methoxy)benzyl]-6,8-dimethyl-2-[2-(4-pyridyl)-ethylamino]purine or a salt thereof, or a hydrate thereof or a solvate thereof.
9-[(3-Cyclopentyloxy-4-methoxy)benzyl]-6,8-dimethyl-2-[(4-pyridyl)-methylamino]purine or a salt thereof, or a hydrate thereof or a solvate thereof.
9-[(3-Cyclopentyloxy-4-methoxy)benzyl]-6,8-dimethyl-2-[3-(4-pyridyl)-propyloxy]purine or a salt thereof, or a hydrate thereof or a solvate thereof.
4-[[9-[(3-Cyclopentyloxy-4-methoxy)benzyl]-6,8-dimethylpurin]-2-yl-3-oxy-propyl]pyridine N-oxide or a salt thereof, or a hydrate thereof or a solvate thereof.
A compound represented by the following formula (A):
- wherein R1 represents a C1-C4 alkyl group or difluoromethyl group;
- R2 represents tetrahydrofuranyl group, a C1-C7 alkyl group, a C1-C7 haloalkyl group, a C2-C7 alkenyl group, bicyclo[2,2,1]hept-2-yl group, or a C3-C8 cycloalkyl group;
- R4 represents hydrogen atom, a halogen atom, a C1-C4 alkyl group, a C1-C4 alkoxyl group, amino group, a C1-C4 alkylamino group, pyrrolidinyl group, morpholino group, a C2-C8 dialkylamino group, or —Y—(CH2)n—B {Y represents —O—, —S—, —NHCO—, or —N(R6)— (R6 represents hydrogen atom or a C1-C4 alkyl group), n represents an integer of from 0 to 4, B represents a phenyl group, a naphthyl group, or a heterocyclic residue, each of which may be substituted, and X2 represents a halogen atom}.
A compound represented by the following formula (B):
- wherein R1 represents a C1-C4 alkyl group or difluoromethyl group;
- R2 represents tetrahydrofuranyl group, a C1-C7 alkyl group, a C1-C7 haloalkyl group, a C2-C7 alkenyl group, bicyclo[2,2,1]hept-2-yl group, or a C3-C8 cycloalkyl group;
- R4 represents hydrogen atom, a halogen atom, a C1-C4 alkyl group, a C1-C4 alkoxyl group, amino group, a C1-C4 alkylamino group, pyrrolidinyl group, morpholino group, a C2-C8 dialkylamino group, or —Y—(CH2)n—B {Y represents —O—, —S—, —NHCO—, or —N(R6)— (R6 represents hydrogen atom or a C1-C4 alkyl group), n represents an integer of from 0 to 4, B represents a phenyl group, a naphthyl group, or a heterocyclic residue, each of which may be substituted, and X2 represents a halogen atom}.
Dependencies are inferred from the claim text.