Pyrido[2,1-A]Isoquinoline derivatives

A compound of formula (I)

• wherein
• R1 is aryl, substituted aryl, heteroaryl, or substituted heteroaryl;
• R2, R3 and R4 are each independently hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy or lower alkenyl, wherein lower alkyl, lower alkoxy and lower alkenyl are optionally substituted by lower alkoxycarbonyl, aryl, substituted aryl, heterocyclyl or substituted heterocyclyl.
• R5 is hydrogen, fluorine, lower alkyl, -aryl or substituted aryl;
• R6 is hydrogen, lower alkyl or hydroxy-lower alkyl, or
• R5 and R6 together with the carbon atoms to which they are attached form a five or six membered saturated carbocyclic ring;
• R7 is hydrogen, fluorine or lower alkyl;
• wherein substituted aryl is aryl that is mono-, di- or tri-substituted by lower alkyl, lower alkoxy, halo, cyano, azido, amino, di-lower alkyl amino or hydroxy;
• substituted heteroaryl is heteroaryl that is mono-, di- or tri-substituted by halogen, amino, perfluoro-lower alkyl, lower alkyl or lower alkoxy;
• substituted heterocyclyl is heterocyclyl that is mono-, di- or tri-substituted by lower alkyl, lower alkoxy, halo, cyano, azido, amino, di-lower alkyl amino or hydroxyl;
• and pharmaceutically acceptable salts thereof.