Assays and reagents for identifying anti-fungal agents, and uses related thereto
AssigneeGPC Biotech AG
InventorsVivian Berlin, Veronique Damagnez, Susan E. Smith
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Abstract
The present invention relates to rapid, reliable and effective assays for screening and identifying pharmaceutically effective compounds that specifically inhibit the biological activity of fungal GTPase proteins, particularly GTPases involved in cell wall integrity, hyphael formation, and/or other cellular functions critical to pathogenesis. Another aspect of the present invention relates to novel Candida genes and gene products.
Claims10
An isolated nucleic acid encoding a geranylgeranyl protein transferase (GGPTase) polypeptide, wherein said polypeptide comprises a sequence at least 90% identical to SEQ ID NO:
- 8 and directs the binding of said polypeptide to other GGPTase subunit(s) or to a Rho1-like GTPase, or a combination thereof.
Dependencies are inferred from the claim text.