Biologically active compounds of Ganoderma pfeifferi DSM 13239
AssigneeGanomycin
InventorsWolf Jülich, Ulrike Lindequist, Rolf Jansen, Ramzi Mothana
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Abstract
The present invention relates to novel biologically active compounds from fungi of the species Ganoderma pfeifferi DSM 13239, processes for their preparation, and their use. From the fruit body and mycelium of the species Ganoderma pfeifferi DSM 13239, extracts can be obtained which have antimicrobial activity and are suitable as preserving agents, for pharmaceutical and cosmetic preparations, for controlling infections, and for use in fish breeding. Antimicrobially active substances called ganomycins having activity against multiresistant germs are isolated from the extracts. The total synthesis of the ganomycins and their derivatization enables their use an antibiotics.
Claims19
A Ganoderma extract comprising a solvent extract of Ganoderma pfeifferi DSM 13239, the extract having biological activity, wherein the biological activity is antimicrobial activity and/or natural-endopeptidase inhibiting activity and/or angiotensin-converting-enzyme inhibiting activity and/or inhibiting serum-mediated-binding-of-lipopolysaccaride inhibiting activity.
The Ganoderma extract of claim 3, wherein Ganoderma pfeifferi DSM 13239 is grown on wood substrates in mushroom farms.
Dependencies are inferred from the claim text.