Medical articles prepared for cell adhesion
AssigneeSt. Jude Medical, Inc.
InventorsWenda C. Carlyle, Avrom M. Brendzel
Life of this patent
Estimating the term…
Abstract
A prosthesis is formed from a biocompatible material having one or more associated cell adhesion stimulating proteins. The biocompatible material can be a ceramic material or a carbon coated material. The cell adhesion stimulating protein can be a structural protein or a polypeptide growth factor, such as vascular endothelial growth factor. Viable cells can be adhered in vivo or in vitro to the biocompatible material with the cell adhesion stimulating protein.
Claims35
A medical article suitable for contacting a patient's bodily fluids comprising a biocompatible material and at least one cell adhesion stimulating protein associated with the biocompatible material, the biocompatible material comprising a ceramic material and the cell adhesion stimulating protein being selected from the group consisting of VEGF, fibroblast growth factor, Tat protein, and combinations thereof, further comprising a layer of viable cells in association with the ceramic material to reduce or inhibit thrombosis.
A method for producing a medical article suitable for contact with a patient's bodily fluids, the method comprising:
- inducing the colonization and proliferation of viable cells to reduce or inhibit thrombosis by adhering a cell adhesion stimulating protein to a ceramic material, the cell adhesion stimulating protein being selected from the group consisting of VEGF, fibroblast growth factor, and combinations thereof.
A method for producing a prosthesis comprising:
- harvesting viable cells from a patient;
- adhering a cell adhesion stimulating protein comprising a growth factor to a ceramic material;
- and
- associating the viable cells with the ceramic material by contacting the ceramic material having adhered said cell adhesion stimulating protein with a cell culture comprising the viable cells.
A method for producing a prosthesis comprising:
- harvesting viable cells from a patient;
- adhering a cell adhesion stimulating protein to a ceramic material;
- and
- associating the viable cells with the ceramic material by contacting the ceramic material having adhered said cell adhesion stimulating protein with a cell culture comprising the viable cells;
- wherein the viable cells comprise endothelial cells, the cell adhesion stimulating protein comprises vascular endothelial growth factor and the ceramic material comprises pyrolytic carbon.
A medical article suitable for contacting a patient's bodily fluids comprising a biocompatible material and at least one cell adhesion stimulating protein associated with the biocompatible material, the biocompatible material comprising a ceramic material and the cell adhesion stimulating protein comprising a structural protein and a growth factor, further comprising a layer of viable cells in association with the ceramic material to reduce or inhibit thrombosis.
A method for producing a medical article suitable for contact with a patient's bodily fluids, the method comprising:
- inducing the colonization and proliferation of viable cells to reduce or inhibit thrombosis by adhering a cell adhesion stimulating protein to a ceramic material, the cell adhesion stimulating protein comprising a structural protein and a growth factor.
Dependencies are inferred from the claim text.