Methods for noninvasive analyte sensing
AssigneeBoard of Regents, The University of Texas System
InventorsMassoud Motamedi, Rinat O. Esenaliev
Life of this patent
Estimating the term…
Abstract
Methods for measuring analyte concentration within a tissue using optical coherence tomography (OCT). Radiation is generated, and a first portion of the radiation is directed to the tissue to generate backscattered radiation. A second portion of the radiation is directed to a reflector to generate reference radiation. The backscattered radiation and the reference radiation is detected to produce an interference signal. The analyte concentration is calculated using the interference signal.
Claims44
A method for measuring glucose concentration within a tissue, comprising:
- generating radiation;
- directing a first portion of the radiation to the tissue to generate backscattered radiation;
- directing a second portion of the radiation to a reflector to generate reference radiation;
- detecting the backscattered radiation and the reference radiation to produce an optical coherence tomography signal;
- and
- calculating the glucose concentration using a slope of the optical coherence tomography signal.
A method for measuring glucose concentration within a tissue, comprising:
- detecting radiation backscattered from the tissue and reference radiation to generate an optical coherence tomography (OCT) signal;
- and
- determining the glucose concentration within the tissue using a slope of the OCT signal.
A method for measuring analyte concentration within a tissue, comprising:
- implanting a probe within the tissue, the probe configured to alter an optical coherence tomography (OCT) signal of the tissue;
- generating an OCT signal of the tissue, the OCT signal being altered by the probe;
- and
- correlating a change in slope of the OCT signal with the analyte concentration within the tissue.
A computer readable media containing program instructions for measuring glucose concentration within a tissue, the computer readable media comprising:
- instructions for storing an optical coherence tomography (OCT) signal in memory;
- and
- instructions for determining the glucose concentration within the tissue using the signal,
- wherein the instructions for determining the glucose concentration comprise:
- determining a slope of the OCT signal;
- and
- determining the glucose concentration using the slope.
A computer readable media containing program instructions for measuring glucose concentration within a tissue, the computer readable media comprising:
- instructions for storing an optical coherence tomography (OCT) signal in memory;
- and
- instructions for determining the glucose concentration within the tissue using the signal,
- wherein the instructions for determining the glucose concentration comprise:
- instructions for correlating a change in the slope with an optical or morphological change in the tissue.
A method for measuring glucose concentration within a tissue, comprising:
- generating radiation;
- directing a first portion of the radiation to the tissue to generate backscattered radiation;
- directing a second portion of the radiation to a reflector to generate reference radiation;
- detecting the backscattered radiation and the reference radiation across a surface and in a depth to produce a two-dimensional image;
- processing the two-dimensional image into a one-dimensional signal;
- and
- calculating the glucose concentration using a slope of the one-dimensional signal.
Dependencies are inferred from the claim text.