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US 6,723,893 B1Granted
Mice having a mutant SOD-1-encoding transgene
AssigneesMassachusetts Institute of Technology, The General Hospital Corporation
InventorsRobert Brown, H. Robert Horvitz, Daniel R. Rosen
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Abstract
Disclosed is the family of genes responsible for the neurodegenerative diseases, particularly Amyotrophic Lateral Sclerosis. Methods and compounds for the diagnosis, prevention, and therapy of the disease are also disclosed.
Claims17
A transgenic mouse having somatic and germ cells containing a transgene, said transgene encoding and expressing a neurodegenerative disease-causing mutant SOD-1 polypeptide.
Dependencies are inferred from the claim text.