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US 6,723,844 B1Granted
Preparation of K-252a
AssigneeAbbott Laboratories
InventorsNavayath Shobana, John C. Strong, Mark W. Tubergen, Russell A. Brierley
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Abstract
The present invention provides a process for the synthesis of K-252a and intermediates useful in the process.
Claims21
A process for preparing the compound of formula (II)
- wherein X is selected from the group consisting of Na, NH4, Li, and K;
- (a) treating the compound of formula (I)
- with an aqueous hydroxide base;
- (b) crystallizing the product of step (a);
- and
- (c) isolating the product of step (b).
3 more elements
A process for preparing the compound of formula (II), the process comprising:
- (a) treating the compound of formula (I) with aqueous sodium hydroxide;
- (b) cooling the product of step (a);
- (c) optionally partially concentrating the product of step (b);
- and
- (d) isolating the product of step (b) or step (c) by filtration.
2 more elements
A process for preparing the compound of formula (III)
- the process comprising:
- (a) dissolving the compound of formula (II)
- in a solvent;
- (b) optionally treating the solution of step (a) with a base;
- (c) treating the solution of step (a) or step (b) with methyl p-toluenesulfonate;
- and
- (d) isolating the product of step (c).
4 more elements
A process for preparing the compound of formula (III)
- the process comprising:
- (a) treating the compound of formula (I)
- with an aqueous hydroxide base;
- (b) crystallizing the product of step (a);
- (c) isolating the product of step (b);
- (d) dissolving the product of step (e) in a solvent;
- (e) optionally treating the solution of step (d) with a base;
- and
- (f) reacting the product of step (d) or step (e) with a methylating agent.
6 more elements
Dependencies are inferred from the claim text.