# US 6,723,830 B2 · Short peptides which selectively modulate the activity of protein kinases

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- Number: US 6,723,830 B2
- Document ID: US6723830B2
- Status: Granted
- Kind: B2
- Application number: 10/038,612
- Filed: 2002-01-08
- Published: 2002-10-31
- Granted: 2004-04-20
- Earliest claimed: 1998-09-25
- Assignees: Children's Medical Center Corporation; Yissum Research Development Company
- Inventors: Shmuel A. Ben-Sasson
- Web page: https://patentgrep.com/patent/US6723830B2

## CPC

- C12N 9/1205: {Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases}
- A61P 1/00: Drugs for disorders of the alimentary tract or the digestive system
- A61P 3/10: for hyperglycaemia, e.g. antidiabetics
- A61P 7/02: Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A61P 9/00: Drugs for disorders of the cardiovascular system
- A61P 9/10: for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A61P 9/12: Antihypertensives
- A61P 11/06: Antiasthmatics
- A61P 13/12: of the kidneys
- A61P 17/06: Antipsoriatics
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 25/18: Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A61P 25/28: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 35/00: Antineoplastic agents
- A61P 37/00: Drugs for immunological or allergic disorders
- A61P 37/06: Immunosuppressants, e.g. drugs for graft rejection
- A61K 38/00: Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00)
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

Peptides which are peptide derivatives of the αD region of a protein kinase can modulate the activity of protein kinases. The activity of a protein kinase in a subject can be modulated by administering one or more of these peptides.

## Claims

### Claim 1

A peptide capable of modulating the activity of a protein kinase having a structure that includes the twelve subdomains and nine alpha helices that are characteristic of the protein kinase superfamily, consisting of:
a) an αD region peptide consisting of a sequence of about 20 amino acid residues of the protein kinase Subdomain V and the beginning of Subdomain VI, beginning at the end of the b5 beta sheet and extending through the D helix and the following loop to the beginning of helix E, which amino acids correspond to a continuous stretch of the prototypical PKA-Cα in positions 120-139 of the PKA-Cα, and which αD region peptide modulates the activity of the protein kinase;
b) a subsequence peptide consisting of a subsequence of a) consisting of at least five contiguous amino acids thereof, which subsequence peptide modulates the activity of the protein kinase;
c) a modified sequence peptide having a modified sequence of a) or b) in which up to two residues are each substituted by another amino acid residue or amino acid residue analog other than one which is identical to the one being substituted except that a functional group in the side chain is functionalized with a protecting group, which modified sequence peptide modulates the activity of the protein kinase;
d) a protected peptide a), b) or c) in which the N-terminus and/or the C-terminus is protected by a protecting group and/or one or more side chains of the amino acid residues of the peptide of a), b) or c) have been functionalized with a protecting group, which protected peptide modulates the activity of the protein kinase; or
e) a cyclized peptide of a), b), c) or d) which has been cyclized, which cyclized peptide modulates the activity of the protein kinase, wherein the peptide has the sequence of SEQ ID NO:95, SEQ ID NO:96, SEQ ID NO:97, SEQ ID NO:98, SEQ ID NO:99, SEQ ID NO:100, SEQ ID NO:101, SEQ ID NO:102, SEQ ID NO:103, SEQ ID NO:104, SEQ ID NO:105, SEQ ID NO:106, SEQ ID NO:107, SEQ ID NO:108, SEQ ID NO:109, SEQ ID NO:110, SEQ ID NO:111, SEQ ID NO:112, SEQ ID NO:113, SEQ ID NO:114 SEQ ID NO:115, SEQ ID NO:116, SEQ ID NO:117, SEQ ID NO:118, SEQ ID NO:119, SEQ ID NO:120, SEQ ID NO:121, SEQ ID NO:122, SEQ ID NO:123, SEQ ID NO:124, SEQ ID NO:125, SEQ ID NO:126, SEQ ID NO:127, SEQ ID NO:128, SEQ ID NO:129, SEQ ID NO:130, SEQ ID NO:131, SEQ ID NO:132, SEQ ID NO:133, SEQ ID NO:134, SEQ ID NO:135, SEQ ID NO:136, SEQ ID NO:137, SEQ ID NO:138, SEQ ID NO:139, SEQ ID NO:140, SEQ ID NO:141, SEQ ID NO:142, SEQ ID NO:143, SEQ ID NO:144, SEQ ID NO:145, SEQ ID NO:146, SEQ ID NO:147, SEQ ID NO:148, SEQ ID NO:149, SEQ ID NO:150, SEQ ID NO:151, SEQ ID NO:152, SEQ ID NO:153, SEQ ID NO:154, SEQ ID NO:155, SEQ ID NO:156, SEQ ID NO:157, SEQ ID NO:158, SEQ ID NO:159, SEQ ID NO:160, SEQ ID NO:161, SEQ ID NO:162, SEQ ID NO:163, SEQ ID NO:164, SEQ ID NO:165, SEQ ID NO:166, SEQ ID NO:167, SEQ ID NO:168, SEQ ID NO:169, or SEQ ID NO:170.

### Claim 2

A peptide having the sequence of SEQ ID NO:95, SEQ ID NO:96, SEQ ID NO:97, SEQ ID NO:98, SEQ ID NO:99, SEQ ID NO:100, SEQ ID NO:101, SEQ ID NO:102, SEQ ID NO:103, SEQ ID NO:104, SEQ ID NO:105, SEQ ID NO:106, SEQ ID NO:107, SEQ ID NO:108, SEQ ID NO:109, SEQ ID NO:110, SEQ ID NO:111, SEQ ID NO:112, SEQ ID NO:113, SEQ ID NO:114, SEQ ID NO:115, SEQ ID NO:116, SEQ ID NO:117, SEQ ID NO:118, SEQ ID NO:119, SEQ ID NO:120, SEQ ID NO:121, SEQ ID NO:122, SEQ ID NO:123, SEQ ID NO:124, SEQ ID NO:125, SEQ ID NO:126, SEQ ID NO:127, SEQ ED NO:128, SEQ ID NO:129, SEQ ID NO:130, SEQ ID NO:131, SEQ ID NO:132, SEQ ID NO:133, SEQ ID NO:134, SEQ ID NO:135, SEQ ID NO:136, SEQ ID NO:137, SEQ ID NO:138, SEQ ID NO:139, SEQ ID NO:140, SEQ ID NO:141, SEQ ID NO:142, SEQ ID NO:143, SEQ ID NO:144, SEQ ID NO:145, SEQ ID NO:146, SEQ ID NO:147, SEQ ID NO:148, SEQ ID NO:149, SEQ ID NO:150, SEQ ID NO:151, SEQ ID NO:152, SEQ ID NO:153, SEQ ID NO:154, SEQ ID NO:155, SEQ ID NO:156, SEQ ID NO:157, SEQ ID NO:158, SEQ ID NO:159, SEQ ID NO:160, SEQ ID NO:161, SEQ ID NO:162, SEQ ID NO:163, SEQ ID NO:164, SEQ ID NO:165, SEQ ID NO:166, SEQ ID NO:167, SEQ ID NO:168, SEQ ID NO:169, or SEQ ID NO:170, with the proviso that any one amino acid residue in the peptide can be substituted by another amino acid residue or amino acid residue analog.

### Claim 3

A peptide consisting of a sequence of amino acids AA1 through AA23 or a subsequence thereof comprising at least five amino acids, wherein:
AA1 is selected from the group consisting of leucine, methionine, isoleucine and valine;
AA2 is selected from the group consisting of aspartic acid, threonine, glutamic acid, serine and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of a glutamic acid or aspartic acid;
AA3 is selected from the group consisting of leucine, isoleucine, methionine and valine;
AA4 is selected from the group consisting of methionine, isoleucine, leucine and valine;
AA5 is selected from the group consisting of asparagine and glutamine;
AA6 is selected from the group consisting of glycine and alanine;
AA7 is selected from the group consisting of glycine and alanine;
AA8 is selected from the group consisting of aspartic acid, glutamic acid and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of a glutamic acid or aspartic acid;
AA9 is selected from the group consisting of leucine, isoleucine, methionine and valine;
AA10 is selected from the group consisting of histidine, arginine and lysine;
AA11 is selected from the group consisting of tyrosine, phenylalanine and tryptophan;
AA12 is histidine;
AA13 is selected from the group consisting of leucine, isoleucine, methionine and valine;
AA14 is selected from the group consisting of serine, tyrosine, threonine, phenylalanine and tryptophan;
AA15 is selected from the group consisting of glutamine, asparagine and histidine;
AA16 is selected from the group consisting of histidine, valine, leucine, methionine and isoleucine;
AA17 is selected from the group consisting of glycine, aspartic acid, glutamic acid, alanine and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of a glutamic acid or aspartic acid;
AA18 is selected from the group consisting of valine, glutamic acid, asparagine, glutamine, isoleucine, leucine, methionine, aspartic acid and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of a glutamic acid or aspartic acid;
AA19 is selected from the group consisting of phenylalanine, aspartic acid, proline, alanine, tryptophan, tyrosine, glutamic acid, glycine and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of a glutamic acid or aspartic acid;
AA20 is selected from the group consisting of asparagine, glycine, glutamine and alanine;
AA21 is selected from the group consisting of proline, phenylalanine, tryptophan and tyrosine;
AA22 is selected from the group consisting of glycine and alanine; and
AA23 is selected from the group consisting of phenylalanine, tryptophan and tyrosine, wherein the sequence AA1 through AA23 or a subsequence thereof corresponds to the sequence or a subsequence of the αD region of a G protein-coupled receptor kinase selected from the group consisting of SEQ ID NO:18, SEQ ID NO:19, SEQ ID NO:20, SEQ ID NO:21 and SEQ ID NO:22, with the proviso that any one amino acid in the sequence AA1 through AA23 or the subsequence thereof can vary as set forth above.

### Claim 4

A peptide consisting of a sequence of amino acids AA1 through AA20 or a subsequence thereof comprising at least seven amino acids, wherein:
AA1 is selected from the group consisting of phenylalanine, tryptophan and tyrosine;
AA2 is selected from the group consisting of glutamic acid, aspartic acid and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA3 is selected from the group consisting of phenylalanine, histidine, tryptophan and tyrosine;
AA4 is selected from the group consisting of leucine, valine, isoleucine and methionine;
AA5 is selected from the group consisting of histidine, aspartic acid, glutamic acid, and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA6 is selected from the group consisting of glutamine and asparagine;
AA7 is selected from the group consisting of aspartic acid, glutamic acid and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA8 is selected from the group consisting of leucine, isoleucine, methionine and valine;
AA9 is selected from the group consisting of lysine, arginine, threonine and serine;
AA10 is selected from the group consisting of lysine, threonine, arginine and serine;
AA11 is selected from the group consisting of phenylalanine, tyrosine and tryptophan;
AA12 is selected from the group consisting of methionine, leucine, isoleucine and valine;
AA13 is selected from the group consisting of aspartic acid, glutamic acid and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA14 is selected from the group consisting of alanine, lysine, arginine and glycine;
AA15 is selected from the group consisting of valine, serine, alanine, isoleucine, leucine, methionine and threonine;
AA16 is selected from the group consisting of alanine, proline and glycine;
AA17 is selected from the group consisting of leucine, proline, glutamic acid, isoleucine, methionine, valine, aspartic acid and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA18 is selected from the group consisting of threonine, proline and serine;
AA19 is selected from the group consisting of glycine and alanine; and
AA20 is selected from the group consisting of isoleucine, leucine, valine and methionine.

### Claim 5 (depends on 4)

The peptide of claim 4 wherein the sequence AA1 through AA20 or a subsequence thereof corresponds to a sequence of the αD region of a cyclin dependent kinase selected from the group consisting of SEQ ID NO:35, SEQ ID NO:36 and SEQ ID NO:37 or a subsequence thereof, with the proviso that any two amino acids in the sequence AA1 through AA20 or the subsequence thereof can vary as set forth in claim 4.

### Claim 6 (depends on 4)

The peptide of claim 4 wherein the sequence AA1 through AA20 or a subsequence thereof corresponds to a sequence of the αD region of a cyclin dependent kinase selected from the group consisting of SEQ ID NO:35, SEQ ID NO:36 and SEQ ID NO:37 or a subsequence thereof, with the proviso that any one amino acid in the sequence AA1 through AA20 or the subsequence thereof can vary as set forth in claim 4.

### Claim 7

A peptide consisting of a sequence of amino acids AA1 through AA21 or a subsequence thereof comprising at least seven amino acids, wherein:
AA1 is selected from the group consisting of threonine, methionine, serine, isoleucine, leucine and valine;
AA2 is selected from the group consisting of glutamic acid, aspartic acid and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA3 is selected from the group consisting of phenylalanine, tyrosine, histidine and tryptophan;
AA4 is selected from the group consisting of methionine, valine, isoleucine and leucine;
AA5 is selected from the group consisting of serine, asparagine, cysteine, alanine, glutamic acid, threonine, glutamine, aspartic acid, glycine and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA6 is selected from the group consisting of lysine, histidine, asparagine, arginine and glutamine;
AA7 is selected from the group consisting of glycine and alanine;
AA8 is selected from the group consisting of serine, asparagine, threonine and glutamine;
AA9 is selected from the group consisting of leucine, isoleucine, methionine and valine;
AA10 is selected from the group consisting of leucine, valine, isoleucine and methionine;
AA11 is selected from the group consisting of aspartic acid, asparagine, glutamic acid, glutamine and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA12 is selected from the group consisting of phenylalanine, tyrosine and tryptophan;
AA13 is selected from the group consisting of leucine, isoleucine, methionine and valine;
AA14 is selected from the group consisting of lysine and arginine;
AA15 is selected from the group consisting of glycine, glutamic acid, aspartic acid, asparagine, serine, threonine, glutamine, alanine and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA16 is selected from the group consisting of glutamic acid, glycine, proline, aspartic acid, arginine, lysine, alanine and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA17 is selected from the group consisting of threonine, serine, aspartic acid, glutamic acid, glycine, alanine and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA18 is selected from the group consisting of glycine, arginine, lysine and alanine;
AA19 is selected from the group consisting of lysine, arginine, glutamine, glycine, serine, isoleucine, alanine, asparagine, threonine, leucine, methionine and valine;
AA20 is selected from the group consisting of tyrosine, alanine, aspartic acid, lysine, valine, leucine, phenylalanine, tryptophan, glutamic acid, arginine, isoleucine, methionine, glycine and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid; and
AA21 is selected from the group consisting of leucine, valine, glutamine, isoleucine, methionine and asparagine.

### Claim 8 (depends on 7)

The peptide of claim 7 wherein the sequence AA1 through AA21 or a subsequence thereof corresponds to the sequence of the αD region of a Src family kinase selected from the group consisting of SEQ ID NO:38, SEQ ID NO:39, SEQ ID NO:40, SEQ ID NO:41, SEQ ID NO:42, SEQ ID NO:43, SEQ ID NO:44, SEQ ID NO:45 and SEQ ID NO:46 or a subsequence thereof, with the proviso that any two amino acids in the sequence AA1 through AA21 or the subsequence thereof can vary as set forth in claim 7.

### Claim 9 (depends on 7)

The peptide of claim 7 wherein the sequence AA1 through AA21 or a subsequence thereof corresponds to the sequence of the αD region of a Src family kinase selected from the group consisting of SEQ ID NO:38, SEQ ID NO:39, SEQ ID NO:40, SEQ ID NO:41, SEQ ID NO:42, SEQ ID NO:43, SEQ ID NO:44, SEQ ID NO:45 and SEQ ID NO:46 or a subsequence thereof, with the proviso that any one amino acid in the sequence AA1 through AA21 or the subsequence thereof can vary as set forth in claim 7.

### Claim 10

A peptide consisting of a sequence of amino acids AA1 through AA39 or a subsequence thereof comprising at least seven amino acids, wherein:
AA1 is selected from the group consisting of isoleucine, threonine, valine, leucine, methionine and serine;
AA2 is selected from the group consisting of glutamic acid, aspartic acid and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA3 is selected from the group consisting of tyrosine, phenylalanine and tryptophan;
AA4 is selected from the group consisting of alanine, cysteine, serine, thronine and glycine;
AA5 is selected from the group consisting of glycine, arginine, phenylalanine, lysine, tryptophan and tyrosine;
AA6 is selected from the group consisting of tyrosine, histidine, phenylalanine and tryptophan;
AA7 is selected from the group consisting of glycine and alanine;
AA8 is selected from the group consisting of asparagine, aspartic acid, glutamine, glutamic acid and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA9 is selected from the group consisting of leucine, isoleucine, methionine and valine;
AA10 is selected from the group consisting of leucine, valine, serine, isoleucine, methionine and threonine;
AA11 is selected from the group consisting of aspartic acid, asparagine, threonine, glutamic acid, glutamine, serine and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA12 is selected from the group consisting of phenylalanine, tyrosine and tryptophan;
AA13 is selected from the group consisting of leucine, isoleucine, methionine and valine;
AA14 is selected from the group consisting of arginine, histidine and lysine;
AA15 is selected from the group consisting of lysine, arginine, serine, alanine, glycine and threonine;
AA16 is selected from the group consisting of serine, asparagine, lysine, threonine, glutamine and arginine;
AA17 is selected from the group consisting of arginine and lysine;
AA18 is selected from the group consisting of valine, histidine, aspartic acid, asparagine, isoleucine, leucine, methionine, glutamic acid, glutamine and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA19 is selected from the group consisting of leucine, threonine, serine, alanine, glutamic acid, isoleucine, methionine, valine, aspartic acid, glycine and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA20 is selected from the group consisting of glutamic acid, phenylalanine, aspartic acid, tryptophan, tyrosine and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA21 is selected from the group consisting of threonine, leucine, phenylalanine, serine, valine, isoleucine, methionine, tryptophan and tyrosine;
AA22 is selected from the group consisting of aspartic acid, glutamine, serine, leucine, proline, glutamic acid, asparagine, threonine, isoleucine, methionine, valine and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA23 is selected from the group consisting of proline, histidine, asparagine, cysteine, tyrosine, glutamine, phenylalanine, tryptophan, and serine;
AA24 is selected from the group consisting of alanine, histidine, lysine, arginine and glycine;
AA25 is selected from the group consisting of phenylalanine, serine, proline, aspartic acid, glutamic acid, tryptophan, tyrosine, threonine and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA26 is selected from the group consisting of alanine, aspartic acid, glutamic acid, lysine, arginine, glycine and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA27 is selected from the group consisting of arginine, isoleucine, lysine, alanine, serine, glycine, leucine, methionine, valine and threonine;
AA28 is selected from the group consisting of glutamic acid, alanine, arginine, proline, leucine, aspartic acid, lysine, isoleucine, methionine, valine, glycine and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA29 is selected from the group consisting of histidine, asparagine, arginine, lysine, glutamic acid, glutamine, aspartic acid and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA30 is selected from the group consisting of glycine, serine, proline, lysine, methionine, glutamine, phenylalanine, threonine, arginine, isoleucine, leucine, valine, asparagine, tryptophan, tyrosine and alanine;
AA31 is selected from the group consisting of threonine, proline, glutamic acid, arginine, serine, aspartic acid, lysine and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA32 is selected from the group consisting of serine, alanine, aspartic acid, lysine, arginine, glycine, threonine, glutamic acid and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA33 is selected from the group consisting of threonine, glutamic acid, isoleucine, lysine, phenylalanine, serine, aspartic acid, leucine, methionine, valine, arginine, tryptophan, tyrosine and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA34 is selected from the group consisting of leucine, phenylalanine, glutamic acid, arginine, aspartic acid, isoleucine, methionine, valine, tryptophan, tyrosine, lysine and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA35 is selected from the group consisting of tyrosine, glycine, lysine, alanine, phenylalanine, tryptophan and arginine;
AA36 is selected from the group consisting of serine, leucine, methionine, valine, threonine, and isoleucine;
AA37 is selected from the group consisting of asparagine, glutamic acid, valine, glycine, glutamine, aspartic acid, isoleucine, leucine, methionine, alanine and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA38 is selected from the group consisting of alanine, proline, glutamic acid, aspartic acid, glycine and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA39 is selected from the group consisting of leucine, alanine, glycine, isoleucine, methionine and valine, wherein the sequence AA1 through AA39 or a subsequence thereof corresponds to the sequence of the αD region of an endothelial growth factor receptor kinase selected from the group consisting of SEQ ID NO:49 and SEQ ID NO:50 or a subsequence thereof, with the proviso that any two amino acids in the sequence AA1 through AA39 or the subsequence thereof can vary as set forth above.

### Claim 11

A peptide consisting of a sequence of amino acids AA1 through AA39 or a subsequence thereof comprising at least seven amino acids, wherein:
AA1 is selected from the group consisting of isoleucine, threonine, valine, leucine, methionine and serine;
AA2 is selected from the group consisting of glutamic acid, aspartic acid and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA3 is selected from the group consisting of tyrosine, phenylalanine and tryptophan;
AA4 is selected from the group consisting of alanine, cysteine, serine, thronine and glycine;
AA5 is selected from the group consisting of glycine, arginine, phenylalanine, lysine, tryptophan and tyrosine;
AA6 is selected from the group consisting of tyrosine, histidine, phenylalanine and tryptophan;
AA7 is selected from the group consisting of glycine and alanine;
AA8 is selected from the group consisting of asparagine, aspartic acid, glutamine, glutamic acid and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA9 is selected from the group consisting of leucine, isoleucine, methionine and valine;
AA10 is selected from the group consisting of leucine, valine, serine, isoleucine, methionine and threonine;
AA11 is selected from the group consisting of aspartic acid, asparagine, threonine, glutamic acid, glutamine, serine and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA12 is selected from the group consisting of phenylalanine, tyrosine and tryptophan;
AA13 is selected from the group consisting of leucine, isoleucine, methionine and valine;
AA14 is selected from the group consisting of arginine, histidine and lysine;
AA15 is selected from the group consisting of lysine, arginine, serine, alanine, glycine and threonine;
AA16 is selected from the group consisting of serine, asparagine, lysine, threonine, glutamine and arginine;
AA17 is selected from the group consisting of arginine and lysine;
AA18 is selected from the group consisting of valine, histidine, aspartic acid, asparagine, isoleucine, leucine, methionine, glutamic acid, glutamine and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA19 is selected from the group consisting of leucine, threonine, serine, alanine, glutamic acid, isoleucine, methionine, valine, aspartic acid, glycine and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA20 is selected from the group consisting of glutamic acid, phenylalanine, aspartic acid, tryptophan, tyrosine and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA21 is selected from the group consisting of threonine, leucine, phenylalanine, serine, valine, isoleucine, methionine, tryptophan and tyrosine;
AA22 is selected from the group consisting of aspartic acid, glutamine, serine, leucine, proline, glutamic acid, asparagine, threonine, isoleucine, methionine, valine and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA23 is selected from the group consisting of proline, histidine, asparagine, cysteine, tyrosine, glutamine, phenylalanine, tryptophan, and serine;
AA24 is selected from the group consisting of alanine, histidine, lysine, arginine and glycine;
AA25 is selected from the group consisting of phenylalanine, serine, proline, aspartic acid, glutamic acid, tryptophan, tyrosine, threonine and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA26 is selected from the group consisting of alanine, aspartic acid, glutamic acid, lysine, arginine, glycine and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA27 is selected from the group consisting of arginine, isoleucine, lysine, alanine, serine, glycine, leucine, methionine, valine and threonine;
AA28 is selected from the group consisting of glutamic acid, alanine, arginine, proline, leucine, aspartic acid, lysine, isoleucine, methionine, valine, glycine and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA29 is selected from the group consisting of histidine, asparagine, arginine, lysine, glutamic acid, glutamine, aspartic acid and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA30 is selected from the group consisting of glycine, serine, proline, lysine, methionine, glutamine, phenylalanine, threonine, arginine, isoleucine, leucine, valine, asparagine, tryptophan, tyrosine and alanine;
AA31 is selected from the group consisting of threonine, proline, glutamic acid, arginine, serine, aspartic acid, lysine and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA32 is selected from the group consisting of serine, alanine, aspartic acid, lysine, arginine, glycine, threonine, glutamic acid and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA33 is selected from the group consisting of threonine, glutamic acid, isoleucine, lysine, phenylalanine, serine, aspartic acid, leucine, methionine, valine, arginine, tryptophan, tyrosine and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA34 is selected from the group consisting of leucine, phenylalanine, glutamic acid, arginine, aspartic acid, isoleucine, methionine, valine, tryptophan, tyrosine, lysine and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA35 is selected from the group consisting of tyrosine, glycine, lysine, alanine, phenylalanine, tryptophan and arginine;
AA36 is selected from the group consisting of serine, leucine, methionine, valine, threonine, and isoleucine;
AA37 is selected from the group consisting of asparagine, glutamic acid, valine, glycine, glutamine, aspartic acid, isoleucine, leucine, methionine, alanine and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA38 is selected from the group consisting of alanine, proline, glutamic acid, aspartic acid, glycine and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA39 is selected from the group consisting of leucine, alanine, glycine, isoleucine, methionine and valine, wherein the sequence AA1 through AA39 or a subsequence thereof corresponds to the sequence of the αD region of an endothelial growth factor receptor kinase selected from the group consisting of SEQ ID NO:49 and SEQ ID NO:50 or a subsequence thereof, with the proviso that any one amino acid in the sequence AA1 through AA39 or the subsequence thereof can vary as set forth above.

### Claim 12

A peptide consisting of a sequence of amino acids AA1 through AA34 or a subsequence thereof comprising at least seven amino acids, wherein:
AA1 is selected from the group consisting of valine, isoleucine, leucine and methionine;
AA2 is selected from the group consisting of glutamic acid, aspartic acid and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA3 is selected from the group consisting of tyrosine, cysteine, phenylalanine, tryptophan and serine;
AA4 is selected from the group consisting of alanine and glycine;
AA5 is selected from the group consisting of serine, alanine, threonine and glycine;
AA6 is selected from the group consisting of lysine and arginine;
AA7 is selected from the group consisting of glycine and alanine;
AA8 is selected from the group consisting of asparagine and glutamine;
AA9 is selected from the group consisting of leucine, isoleucine, methionine and valine;
AA10 is selected from the group consisting of arginine and lysine;
AA11 is selected from the group consisting of glutamic acid, aspartic acid and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA12 is selected from the group consisting of tyrosine, phenylalanine and tryptophan;
AA13 is selected from the group consisting of leucine, isoleucine, methionine and valine;
AA14 is selected from the group consisting of glutamine, arginine, asparagine and lysine;
AA15 is selected from the group consisting of alanine and glycine;
AA16 is selected from the group consisting of arginine and lysine;
AA17 is selected from the group consisting of arginine and lysine;
AA18 is proline;
AA19 is proline;
AA20 is selected from the group consisting of glycine and alanine;
AA21 is selected from the group consisting of leucine, methionine, proline, isoleucine and valine;
AA22 is selected from the group consisting of glutamic acid, aspartic acid and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA23 is selected from the group consisting of tyrosine, leucine, phenylalanine, tryptophan, isoleucine, methionine and valine;
AA24 is selected from the group consisting of cysteine, serine and threonine;
AA25 is selected from the group consisting of tyrosine, phenylalanine, proline and tryptophan;
AA26 is selected from the group consisting of asparagine, aspartic acid, glutamine, glutamic acid and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA27 is selected from the group consisting of proline, isoleucine, threonine, glycine, leucine, methionine, valine, serine and alanine;
AA28 is selected from the group consisting of serine, asparagine, cysteine, proline, threonine and glutamine;
AA29 is selected from the group consisting of histidine, arginine and lysine;
AA30 is selected from the group consisting of asparagine, valine, proline, serine, glutamine, isoleucine, leucine, methionine and threonine;
AA31 is selected from the group consisting of proline, serine and threonine;
AA32 is selected from the group consisting of glutamic acid, glycine, aspartic acid, alanine and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA33 is selected from the group consisting of glutamine, proline and asparagine; and
AA34 is selected from the group Consisting of leucine, methionine, isoleucine and valine.

### Claim 13 (depends on 12)

The peptide of claim 12, wherein the sequence AA1 through AA34 or a subsequence thereof corresponds to the sequence of the αD region of a fibroblast growth factor receptor kinase selected from the group consisting of a subsequence of SEQ ID NO:51, a subsequence of SEQ ID NO:52, a subsequence of SEQ ID NO:53 and a subsequence of SEQ ID NO:54, with the proviso that any two amino acids in the subsequence can vary as set forth in claim 12.

### Claim 14 (depends on 12)

The peptide of claim 12, wherein the sequence AA1 through AA34 or a subsequence thereof corresponds to the sequence of the αD region of a fibroblast growth factor receptor kinase selected from the group consisting of a subsequence of SEQ ID NO:51, a subsequence of SEQ ID NO:52, a subsequence of SEQ ID NO:53 and a subsequence of SEQ ID NO:54, with the proviso that any one amino acid in the subsequence can vary as set forth in claim 12.

### Claim 15

A peptide consisting of a sequence of amino acids AA1 through AA20 or a subsequence thereof comprising at least five amino acids, wherein:
AA1 is selected from the group consisting of methionine, isoleucine, leucine and valine;
AA2 is selected from the group consisting of glutamic acid, aspartic acid and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA3 is selected from the group consisting of phenylalanine, tyrosine, and tryptophan;
AA4 is selected from the group consisting of leucine, isoleucine, methionine and valine;
AA5 is proline;
AA6 is selected from the group consisting of serine, tyrosine, threonine, phenylalanine, tryptophan, leucine and isoleucine;
AA7 is selected from the group consisting of glycine and alanine;
AA8 is selected from the group consisting of serine, cysteine and threonine;
AA9 is selected from the group consisting of leucine, isoleucine, methionine and valine;
AA10 is selected from the group consisting of lysine and arginine;
AA11 is selected from the group consisting of glutamic acid, aspartic acid and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA12 is selected from the group consisting of tyrosine, phenylalanine and tryptophan;
AA13 is selected from the group consisting of leucine, isoleucine, methionine and valine;
AA14 is selected from the group consisting of proline, glutamine, and asparagine;
AA15 is selected from the group consisting of lysine and arginine;
AA16 is selected from the group consisting of asparagine, histidine and glutamine;
AA17 is selected from the group consisting of lysine, arginine, serine and threonine;
AA18 is selected from the group consisting of asparagine, glutamic acid, alanine, glutamine, aspartic acid, glycine, isoleucine, leucine and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA19 is selected from the group consisting of lysine and arginine; and
AA20 is selected from the group consisting of isoleucine, leucine, methionine and valine.

### Claim 16 (depends on 15)

The peptide of claim 15 wherein the sequence AA1 through AA20 or a subsequence thereof corresponds to the sequence of the αD region of a Tyk/Jak kinase selected from the group consisting of SEQ ID NO:73, SEQ ID NO:74, SEQ ID NO:75 and SEQ ID NO:76 or a subsequence thereof, with the proviso that any two amino acids in the sequence AA1 through AA20 or the subsequence thereof can vary as set forth in claim 15.

### Claim 17 (depends on 15)

The peptide of claim 15 wherein the sequence AA1 through AA20 or a subsequence thereof corresponds to the sequence of the αDregion of a Tyk/Jak kinase selected from the group consisting of SEQ ID NO:73, SEQ ID NO:74, SEQ ID NO:75 and SEQ ID NO:76 or a subsequence thereof, with the proviso that any one amino acid in the sequence AA1 through AA20 or the subsequence thereof can vary as set forth in claim 15.

### Claim 18

A peptide consisting of a sequence of amino acids AA1 through AA31 or a subsequence thereof comprising at least five amino acids, wherein:
AA1 is selected from the group consisting of methionine, isoleucine, leucine and valine;
AA2 is selected from the group consisting of glutamic acid, aspartic acid and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA3 is selected from the group consisting of leucine, isoleucine, methionine and valine;
AA4 is selected from the group consisting of methionine, isoleucine, leucine and valine;
AA5 is selected from the group consisting of alanine and glycine;
AA6 is histidine;
AA7 is selected from the group consisting of glycine and alanine;
AA8 is selected from the group consisting of aspartic acid, glutamic acid and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA9 is selected from the group consisting of leucine, isoleucine, methionine and valine;
AA10 is selected from the group consisting of lysine and arginine;
AA11 is selected from the group consisting of serine and threonine;
AA12 is selected from the group consisting of tyrosine, phenylalanine and tryptophan;
AA13 is selected from the group consisting of leucine, isoleucine, methionine and valine;
AA14 is selected from the group consisting of arginine and lysine;
AA15 is selected from the group consisting of serine and threonine;
AA16 is selected from the group consisting of leucine, isoleucine, methionine and valine;
AA17 is selected from the group consisting of arginine and lysine;
AA18 is proline;
AA19 is selected from the group consisting of glutamic acid, aspartic acid and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA20 is selected from the group consisting of alanine and glycine;
AA21 is selected from the group consisting of glutamic acid, aspartic acid and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA22 is selected from the group consisting of asparagine and glutamine;
AA23 is selected from the group consisting of asparagine and glutamine;
AA24 is proline;
AA25 is selected from the group consisting of glycine and alanine;
AA26 is selected from the group consisting of arginine and lysine;
AA27 is proline;
AA28 is proline;
AA29 is proline;
AA30 is selected from the group consisting of threonine and serine; and
AA31 is selected from the group consisting of leucine, isoleucine, methionine and valine, with the proviso that the peptide is not represented by the sequence MAHGDLKSYLRSLRPEAENNP (SEQ ID NO:171).

### Claim 19 (depends on 18)

The peptide of claim 18 wherein the sequence AA1 through AA31 or a subsequence thereof corresponds to the sequence of the αD region of SEQ ID NO:82 or a subsequence thereof, with the proviso that any two amino acids in the sequence AA1 through AA31 or the subsequence thereof can vary as set forth in claim 18.

### Claim 20 (depends on 18)

The peptide of claim 18 wherein the sequence AA1 through AA31 or a subsequence thereof corresponds to the sequence of the αD region of SEQ ID NO:82 or a subsequence thereof, with the proviso that any one amino acid in the sequence AA1 through AA31 or the subsequence thereof can vary as set forth in claim 18.

### Claim 21

A peptide consisting of a sequence of amino acids AA1 through AA18 or a subsequence thereof comprising at least seven amino acids, wherein:
AA1 is selected from the group consisting of threonine and serine;
AA2 is selected from the group consisting of alanine and glycine;
AA3 is selected from the group consisting of phenylalanine, tryptophan and tyrosine;
AA4 is histidine;
AA5 is selected from the group consisting of alanine, glutamic acid, aspartic acid, glycine and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA6 is selected from the group consisting of lysine and arginine;
AA7 is selected from the group consisting of glycine and alanine;
AA8 is selected from the group consisting of asparagine, serine, glutamine and threonine;
AA9 is selected from the group consisting of leucine, isoleucine, methionine and valine;
AA10 is selected from the group consisting of glutamine, serine and threonine;
AA11 is selected from the group consisting of glutamic acid, aspartic acid and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA12 is selected from the group consisting of tyrosine, phenylalanine and tryptophan;
AA13 is selected from the group consisting of leucine, isoleucine, methionine and valine;
AA14 is selected from the group consisting of threonine, lysine, serine and arginine;
AA15 is selected from the group consisting of arginine, alanine, glycine and lysine;
AA16 is selected from the group consisting of histidine, asparagine and glutamine;
AA17 is selected from the group consisting of valine, isoleucine, leucine and methionine; and
AA18 is selected from the group consisting of isoleucine, valine, leucine and methionine.

### Claim 22 (depends on 21)

The peptide of claim 21 wherein the sequence AA1 through AA18 or a subsequence thereof corresponds to the sequence of the αD region of a TGFβ receptor kinase selected from the group consisting of SEQ ID NO:83, SEQ ID NO:84 and SEQ ID NO:85 or a subsequence thereof, with the proviso that any two amino acids in the sequence AA1 through AA18 or the subsequence thereof can vary as set forth in claim 21.

### Claim 23 (depends on 21)

The peptide of claim 21 wherein the sequence AA1 through AA18 or a subsequence thereof corresponds to the sequence of the αD region of a TGFβ receptor kinase selected from the group consisting of SEQ ID NO:83, SEQ ID NO:84 and SEQ ID NO:85 or a subsequence thereof, with the proviso that any one amino acid in the sequence AA1 through AA18 or the subsequence thereof can vary as set forth in claim 21.

### Claim 24

A peptide consisting of a sequence of amino acids AA1 through AA18 or a subsequence thereof comprising at least seven amino acids, wherein:
AA1 is selected from the group consisting of threonine and serine;
AA2 is selected from the group consisting of histidine, aspartic acid, glutamic acid and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA3 is selected from the group consisting of tyrosine, phenylalanine and tryptophan;
AA4 is histidine;
AA5 is selected from the group consisting of glutamic acid, aspartic acid and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA6 is selected from the group consisting of histidine, methionine, asparagine, isoleucine, leucine, valine and glutamine;
AA7 is selected from the group consisting of glycine and alanine;
AA8 is selected from the group consisting of serine and threonine;
AA9 is selected from the group consisting of leucine, isoleucine, methionine and valine;
AA10 is selected from the group consisting of tyrosine, phenylalanine and tryptophan;
AA11 is selected from the group consisting of aspartic acid, glutamic acid and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA12 is selected from the group consisting of phenylalanine, tyrosine and tryptophan;
AA13 is selected from the group consisting of leucine, isoleucine, methionine and valine;
AA14 is selected from the group consisting of glutamine, lysine, asparagine and arginine;
AA15 is selected from the group consisting of arginine, leucine, cysteine, serine, lysine, isoleucine, methionine, valine and threonine;
AA16 is selected from the group consisting of glutamine, threonine, alanine, tyrosine, asparagine, serine, phenylalanine, tryptophan and glycine;
AA17 is selected from the group consisting of threonine and serine; and
AA18 is selected from the group consisting of leucine, valine, isoleucine and methionine.

### Claim 25 (depends on 24)

The peptide of claim 24 wherein the sequence AA1 through AA18 or a subsequence thereof corresponds to the sequence of the αD region of an activin receptor-like kinase selected from the group consisting of SEQ ID NO:86, SEQ ID NO:87, SEQ ID NO:88, SEQ ID NO:89 and SEQ ID NO:90 or a subsequence thereof, with the proviso that any two amino acids in the sequence AA1 through AA18 or the subsequence thereof can vary as set forth in claim 24.

### Claim 26 (depends on 24)

The peptide of claim 24 wherein the sequence AA1 through AA18 or a subsequence thereof corresponds to the sequence of the αD region of an activin receptor-like kinase selected from the group consisting of SEQ ID NO:86, SEQ ID NO:87, SEQ ID NO:88, SEQ ID NO:89 and SEQ ID NO:90 or a subsequence thereof, with the proviso that any one amino acid in the sequence AA1 through AA18 or the subsequence thereof can vary as set forth in claim 24.

### Claim 27

A peptide consisting of a sequence of amino acids AA1 through AA34 or a subsequence thereof comprising at least five amino acids, wherein:
AA1 is selected from the group consisting of phenylalanine, tryptophan and tyrosine;
AA2 is selected from the group consisting of glutamic acid, aspartic acid and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA3 is selected from the group consisting of tyrosine, phenylalanine and tryptophan;
AA4 is selected from the group consisting of methionine, isoleucine, leucine and valine;
AA5 is selected from the group consisting of arginine and lysine;
AA6 is histidine;
AA7 is selected from the group consisting of glycine and alanine;
AA8 is selected from the group consisting of aspartic acid, glutamic acid and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA9 is selected from the group consisting of leucine, isoleucine, methionine and valine;
AA10 is selected from the group consisting of asparagine and glutamine;
AA11 is selected from the group consisting of arginine and lysine;
AA12 is selected from the group consisting of phenylalanine, tryptophan and tyrosine;
AA13 is selected from the group consisting of leucine, isoleucine, methionine and valine;
AA14 is selected from the group consisting of arginine and lysine;
AA15 is selected from the group consisting of serine, alanine, threonine and glycine;
AA16 is histidine;
AA17 is selected from the group consisting of glycine and alanine;
AA18 is proline;
AA19 is selected from the group consisting of aspartic acid, glutamic acid and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA20 is selected from the group consisting of alanine and glycine;
AA21 is selected from the group consisting of lysine, valine, methionine, arginine, isoleucine and leucine;
AA22 is selected from the group consisting of leucine, isoleucine, methionine and valine;
AA23 is selected from the group consisting of leucine, methionine, isoleucine and valine;
AA24 is selected from the group consisting of alanine, valine, isoleucine, leucine, methionine and glycine;
AA25 is selected from the group consisting of glycine, glutamic acid, aspartic acid, alanine and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA26 is selected from the group consisting of glycine and alanine;
AA27 is selected from the group consisting of glutamic acid, asparagine, glutamine, aspartic acid and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA28 is selected from the group consisting of aspartic acid, proline, glutamic acid and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA29 is selected from the group consisting of valine, proline, arginine, isoleucine, leucine, methionine and lysine;
AA30 is selected from the group consisting of alanine, threonine, glutamine, serine, asparagine and glycine;
AA31 is selected from the group consisting of proline, glutamic acid, alanine, aspartic acid, glycine and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA32 is selected from the group consisting of proline, glycine and alanine;
AA33 is selected from the group consisting of leucine, glutamic acid, isoleucine, methionine, valine, aspartic acid and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid; and
AA34 is selected from the group consisting of leucine, isoleucine, methionine and valine, wherein the sequence AA1 through AA34 or a subsequence thereof corresponds to the sequence of the αD region of a neurotrophic receptor kinase selected from the group consisting of SEQ ID NO:68 and SEQ ID NO:69 or a subsequence thereof, with the proviso that any two amino acids in the sequence AA1 through AA34 or the subsequence thereof can vary as set forth above.

### Claim 28

A peptide consisting of a sequence of amino acids AA1 through AA34 or a subsequence thereof comprising at least five amino acids, wherein:
AA1 is selected from the group consisting of phenylalanine, tryptophan and tyrosine;
AA2 is selected from the group consisting of glutamic acid, aspartic acid and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA3 is selected from the group consisting of tyrosine, phenylalanine and tryptophan;
AA4 is selected from the group consisting of methionine, isoleucine, leucine and valine;
AA5 is selected from the group consisting of arginine and lysine;
AA6 is histidine;
AA7 is selected from the group consisting of glycine and alanine;
AA8 is selected from the group consisting of aspartic acid, glutamic acid and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA9 is selected from the group consisting of leucine, isoleucine, methionine and valine;
AA10 is selected from the group consisting of asparagine and glutamine;
AA11 is selected from the group consisting of arginine and lysine;
AA12 is selected from the group consisting of phenylalanine, tryptophan and tyrosine;
AA13 is selected from the group consisting of leucine, isoleucine, methionine and valine;
AA14 is selected from the group consisting of arginine and lysine;
AA15 is selected from the group consisting of serine, alanine, threonine and glycine;
AA16 is histidine;
AA17 is selected from the group consisting of glycine and alanine;
AA18 is proline;
AA19 is selected from the group consisting of aspartic acid, glutamic acid and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA20 is selected from the group consisting of alanine and glycine;
AA21 is selected from the group consisting of lysine, valine, methionine, arginine, isoleucine and leucine;
AA22 is selected from the group consisting of leucine, isoleucine, methionine and valine;
AA23 is selected from the group consisting of leucine, methionine, isoleucine and valine;
AA24 is selected from the group consisting of alanine, valine, isoleucine, leucine, methionine and glycine;
AA25 is selected from the group consisting of glycine, glutamic acid, aspartic acid, alanine and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA26 is selected from the group consisting of glycine and alanine;
AA27 is selected from the group consisting of glutamic acid, asparagine, glutamine, aspartic acid and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA28 is selected from the group consisting of aspartic acid, proline, glutamic acid and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA29 is selected from the group consisting of valine, proline, arginine, isoleucine, leucine, methionine and lysine;
AA30 is selected from the group consisting of alanine, threonine, glutamine, serine, asparagine and glycine;
AA31 is selected from the group consisting of proline, glutamic acid, alanine, aspartic acid, glycine and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA32 is selected from the group consisting of proline, glycine and alanine;
AA33 is selected from the group consisting of leucine, glutamic acid, isoleucine, methionine, valine, aspartic acid and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid; and
AA34 is selected from the group consisting of leucine, isoleucine, methionine and valine, wherein the sequence AA1 through AA18 or a subsequence thereof corresponds to the sequence of the αD region of a neurotrophic receptor kinase selected from the group consisting of SEQ ID NO:68 and SEQ ID NO:69 or a subsequence thereof, with the proviso that any one amino acid in the sequence AA1 through AA31 or the subsequence thereof can vary as set forth above.

### Claim 29

A peptide consisting of a sequence of amino acids AA1 through AA21 or a subsequence thereof comprising at least five amino acids, wherein:
AA1 is selected from the group consisting of threonine and serine;
AA2 is histidine
AA3 is selected from the group consisting of tryptophan, phenylalanine and tyrosine;
AA4 is selected from the group consisting of isoleucine, leucine and methionine;
AA5 is proline;
AA6 is selected from the group consisting of tyrosine, phenylalanine and tryptophan;
AA7 is selected from the group consisting of glycine and alanine;
AA8 is selected from the group consisting of serine and threonine;
AA9 is selected from the group consisting of leucine, isoleucine, methionine and valine;
AA10 is selected from the group consisting of tyrosine, phenylalanine and tryptophan;
AA11 is selected from the group consisting of asparagine and glutamine;
AA12 is selected from the group consisting of valine, isoleucine, leucine and methionine;
AA13 is selected from the group consisting of leucine, isoleucine, methionine and valine;
AA14 is histidine;
AA15 is selected from the group consisting of glutamic acid, aspartic acid and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA16 is selected from the group consisting of glycine and alanine;
AA17 is selected from the group consisting of threonine and serine;
AA18 is selected from the group consisting of asparagine and glutamine;
AA19 is selected from the group consisting of phenylalanine, tryptophan and tyrosine;
AA20 is selected from the group consisting of valine, isoleucine, leucine and methionine; and
AA21 is selected from the group consisting of valine, isoleucine, leucine and methionine.

### Claim 30 (depends on 29)

The peptide of claim 29 wherein the sequence AA1 through AA21 or a subsequence thereof corresponds to the sequence of the αD region of SEQ ID NO:93 or a subsequence thereof, with the proviso that any two amino acids in the sequence AA1 through AA21 or the subsequence thereof can vary as set forth in claim 29.

### Claim 31 (depends on 29)

The peptide of claim 29 wherein the sequence AA1 through AA21 or a subsequence thereof corresponds to the sequence of the αD region of SEQ ID NO:93 or a subsequence thereof, with the proviso that any one amino acid in the sequence AA1 through AA21 or the subsequence thereof can vary as set forth in claim 29.

### Claim 32

A peptide consisting of a sequence of amino acids AA1 through AA22 or a subsequence thereof comprising at least five amino acids, wherein:
AA1 is selected from the group consisting of methionine, isoleucine, leucine and valine;
AA2 is selected from the group consisting of glutamic acid, aspartic acid and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA3 is selected from the group consisting of tyrosine, phenylalanine and tryptophan;
AA4 is selected from the group consisting of cysteine and serine;
AA5 is selected from the group consisting of serine, glutamine, threonine and asparagine;
AA6 is selected from the group consisting of glycine and alanine;
AA7 is selected from the group consisting of glycine and alanine;
AA8 is selected from the group consisting of aspartic acid, glutamic acid and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA9 is selected from the group consisting of leucine, isoleucine, methionine and valine;
AA10 is selected from the group consisting of arginine and lysine;
AA11 is selected from the group consisting of lysine and asparagine;
AA12 is selected from the group consisting of leucine, tyrosine, isoleucine, methionine, valine, phenylalanine and tryptophan;
AA13 is selected from the group consisting of leucine, isoleucine, methionine and valine;
AA14 is selected from the group consisting of asparagine and glutamine;
AA15 is selected from the group consisting of lysine, glutamine, arginine and asparagine;
AA16 is selected from the group consisting of proline, phenylalanine, tryptophan and tyrosine;
AA17 is selected from the group consisting of glutamic acid, aspartic acid and an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic ester of glutamic acid or aspartic acid;
AA18 is selected from the group consisting of asparagine and glutamine;
AA19 is selected from the group consisting of cysteine and serine;
AA20 is selected from the group consisting of cysteine and serine;
AA21 is selected from the group consisting of glycine and alanine; and
AA22 is selected from the group consisting of leucine, isoleucine, methionine and valine.

### Claim 33 (depends on 32)

The peptide of claim 32 wherein the sequence AA1 through AA22 or a subsequence thereof corresponds to the sequence of the αD region of an I-kappa B kinase selected from the group consisting of SEQ ID NO:79 and SEQ ID NO:80 or a subsequence thereof, with the proviso that any two amino acids in the sequence AA1 through AA22 or the subsequence thereof can vary as set forth in claim 32.

### Claim 34 (depends on 32)

The peptide of claim 32 wherein the sequence AA1 through AA22 or a subsequence thereof corresponds to the sequence of the αD region of an I-kappa B kinase selected from the group consisting of SEQ ID NO:79 and SEQ ID NO:80 or a subsequence thereof, with the proviso that any one amino acid in the sequence AA1 through AA22 or the subsequence thereof can vary as set forth in claim 32.