Enzyme inhibitors

A composition for inhibiting enzymes comprising:

• a) from about 0.01% by weight, of one or more polymer conjugates capable of inhibiting one or more proteolytic enzymes having the formula:
• wherein T has a formula selected from the group consisting of:
• xi) and mixtures thereof;
• wherein X is selected from the group consisting of —CH2—, —NH—, —O—, —S—, —CF2—, and mixtures thereof;
• and each D, E, F, and G is independently selected from the group consisting of —CH—, —CH2—, —N—, —NH—, —O—, —S—, —CF2—, and mixtures thereof;
• a) hydrogen;
• b) C1-C18 substituted or unsubstituted, linear or branched alkyl;
• c) C3-C18 substituted or unsubstituted, linear or branched cycloalkyl
• d) C2-C18 substituted or unsubstituted, linear or branched alkenyl;
• e) C2-C18 substituted or unsubstituted, linear or branched alkynyl;
• f) C6-C18 substituted or unsubstituted aryl;
• g) C2-C18 substituted or unsubstituted heterocyclic alkyl;
• h) C3-C18 substituted or unsubstituted heterocyclic alkenyl;
• i) alkylenearyl having the formula:
• —(R1)n—R2
• wherein R1 is C1-C12 linear or branched alkylene, C2-C12 linear or branched alkenylene, or mixtures thereof;
• R2 C6-C18 substituted or unsubstituted aryl, or mixtures thereof;
• n is from 1 to 16;
• j) an amino unit having the formula:
• —(CH2)mN(R3)2
• wherein each R3 is independently C1-C18 substituted or unsubstituted, linear or branched alkyl;
• m is from 0 to 10;
• k) a quaternary ammonium unit having the formula:
• wherein each R3 is independently C1-C18 substituted or unsubstituted, linear or branched alkyl;
• Y is an anion of sufficient charge to provide electronic neutrality;
• m is from 0 to 10;
• l) a unit having the formula:
• wherein R4 is hydrogen, C1-C4 alkyl, or mixtures thereof;
• R5 is hydrogen, C1-C4 alkyl, or mixtures thereof;
• R4 and R5 can be taken together to form a heterocyclic ring comprising from 3 to 5 carbon atoms;
• m) a unit having the formula:
• wherein R6 is hydrogen, C1-C4 alkyl, or mixtures thereof;
• R7 is hydrogen, C1-C4 alkyl, or mixtures thereof;
• R6 and R7 can be taken together to form a heterocyclic ring comprising from 3 to 5 carbon atoms;
• n) a unit having the formula:
• —R8—R9
• wherein R8 is:
• i) —(CH2)p—, wherein p is from 0 to 12;
• ii) —C(O)—;
• iii) —C(X)NR10—, wherein R10 is hydrogen, C1-C4 alkyl, or mixtures thereof;
• X is oxygen, sulfur, NR10, and mixtures thereof;
• iv) —C(X)R11C(X)—, wherein R11 is C1-C18 alkylene, substituted or unsubstituted phenylene. or mixtures thereof;
• X is oxygen, sulfur, NR10, and mixtures thereof;
• v) —C(X)NR10C(X)—, wherein R10 is hydrogen, C1-C4 alkyl, or mixtures thereof;
• X is oxygen, sulfur, NR10, and mixtures thereof;
• vi) —C(X)NR10R11NR10C(X)—, wherein R10 is hydrogen, C1-C4 alkyl, or mixtures thereof;
• R11 is C1-C12 alkylene, substituted or unsubstituted phenylene, or mixtures thereof;
• X is oxygen, sulfur, NR10, and mixtures thereof;
• vii) —NR10C(X)—, wherein R10 is hydrogen, C1-C4 alkyl, or mixtures thereof;
• X is oxygen, sulfur, NR10, and mixtures thereof;
• viii) —NR10C(X)NR10—, wherein R10 is hydrogen, C1-C4 alkyl, or mixtures thereof;
• X is oxygen, sulfur, NR10, and mixtures thereof;
• ix) —NR10C(X)R11NR10—, wherein R10 is hydrogen, C1-C4 alkyl, or mixtures thereof;
• R11 is C1-C12 alkylene, substituted or unsubstituted phenylene, or mixtures thereof;
• X is oxygen, sulfur, NR10, and mixtures thereof;
• x) —NR10R11C(X)NR10—, wherein R10 is hydrogen, C1-C4 alkyl, or mixtures thereof;
• R11 is C1-C12 alkylene, substituted or unsubstituted phenylene, or mixtures thereof;
• x is oxygen, sulfur, NR10, and mixtures thereof;
• xi) —NR10C(X)R11C(X)O—, wherein R10 is hydrogen, C1-C4 alkyl, or mixtures thereof;
• R11 is C1-C12 alkylene, substituted or unsubstituted phenylene, or mixtures thereof;
• X is oxygen, sulfur, NR10, and mixtures thereof;
• xii) —OC(X)R11C(X)NR10—, wherein R10 is hydrogen, C1-C4 alkyl, or mixtures thereof;
• R11 is C1-C12 alkylene, substituted or unsubstituted phenylene, or mixtures thereof;
• X is oxygen, sulfur, NR10, and mixtures thereof;
• xiii) —NR10C(X)NR10R11—, wherein R10 is hydrogen, C1-C4 alkyl, or mixtures thereof;
• R11 is C1-C12 alkylene, substituted or unsubstituted phenylene, or mixtures thereof;
• X is oxygen, sulfur, NR10, and mixtures thereof;
• xiv) —R11NR10C(X)NR10—, wherein R10 is hydrogen, C1-C4 alkyl, or mixtures thereof;
• R11 is C1-C12 alkylene, substituted or unsubstituted phenylene, or mixtures thereof;
• wherein X is oxygen, sulfur, NR10, and mixtures thereof;
• xv) —R11NR10C(X)NR10R11—, wherein R10 is hydrogen, C1-C4 alkyl, or mixtures thereof;
• R11 is C1-C12 alkylene, substituted or unsubstituted phenylene, or mixtures thereof;
• wherein X is oxygen, sulfur, NR10, and mixtures thereof;
• xvi) —NR10, wherein R10 is hydrogen, C1-C4 alkyl, or mixtures thereof;
• xvii) —O—;
• xviii) —(R11)tC(X)(R11)t—;
• wherein R11 is C1-C12 alkylene, substituted or unsubstituted phenylene, or mixtures thereof;
• t is 0 or 1;
• X is oxygen, sulfur, NR10, and mixtures thereof;
• xix) —(R11)tOC(O)(R11)t—;
• wherein R11 is C1-C12 alkylene, substituted or unsubstituted phenylene, or mixtures thereof;
• t is 0 or 1;
• xx) —R11)tC(O)O(R11)t—;
• wherein R11 is C1-C12 alkylene, substituted or unsubstituted phenylene, or mixtures thereof;
• t is 0 or 1;
• xxi) alkyleneoxyalkylene having the formula:
• —(R12O)qR13—
• wherein R12 is C2-C6 linear or branched alkylene, substituted or unsubstituted phenylene;
• R13 is —(CH2)p—, wherein p is from 0 to 12;
• q is from 1 to 4;
• xxii) —S—;
• xxiii) —(R11)tS(R11)t—;
• wherein R11 is C1-C12 alkylene, substituted or unsubstituted phenylene, or mixtures thereof;
• t is 0 or 1;
• xxiv) —(R11)tS(O)(R11)t—;
• wherein R11 is C1-C12 alkylene, substituted or unsubstituted phenylene, or mixtures thereof;
• t is 0 or 1;
• xxv) —(R11)tSO2(R11)t—;
• wherein R11 is C1-C12 alkylene, substituted or unsubstituted phenylene, or mixtures thereof;
• t is 0 or 1;
• xxvi) or mixtures thereof;
• R9 is:
• i) hydrogen;
• ii) C1-C18 substituted or unsubstituted, linear or branched alkyl;
• iii) C3-C18 substituted or unsubstituted, linear or branched cycloalkyl
• iv) C2-C18 substituted or unsubstituted, linear or branched alkenyl;
• v) C2-C18 substituted or unsubstituted, linear or branched alkynyl;
• vi) C6-C18 substituted or unsubstituted aryl;
• vii) C2-C18 substituted or unsubstituted heterocyclic alkyl;
• viii) C3-C18 substituted or unsubstituted heterocyclic alkenyl;
• ix) —OH;
• x) —SO3M;
• xi) —OSO3M;
• xii) —NO2;
• xiii) halogen selected from fluorine, chlorine, bromine, iodine, or mixtures thereof;
• xiv) —C(Hal)3, wherein each Hal is fluorine, chlorine, bromine, iodine, or mixtures thereof;
• xv) —COR14;
• wherein R14 is hydrogen, —OH, C1-C12 alkyl, C1-C12 alkoxy, or mixtures thereof;
• —N(R15)2, or mixtures thereof;
• each R15 is independently hydrogen, —OH, C1-C4 alkyl, or mixtures thereof;
• xvi) —CH(OR14)2 wherein R14 is hydrogen, C1-C12 alkyl, or two R14 units can be taken together to form a ring having from 3 to 5 carbon atoms;
• or mixtures thereof;
• xvii) a unit having the formula:
• wherein R4 is hydrogen, C1-C4 alkyl, or mixtures thereof;
• R5 is hydrogen, C1-C4 alkyl, or mixtures thereof;
• R4 and R5 can be taken together to form a heterocyclic ring comprising from 3 to 5 carbon atoms;
• xviii) a unit having the formula:
• wherein R6 is hydrogen, C1-C4 alkyl, or mixtures thereof;
• R7 is hydrogen, C1-C4 alkyl, or mixtures thereof;
• R6 and R7 can be taken together to form a heterocyclic ring comprising from 3 to 5 carbon atoms;
• xix) —NHOR16, wherein R16 is hydrogen;
• C1-C12 linear or branched alkyl;
• acyl having the formula —COR17, wherein R17 is C1-C4 alkyl;
• or mixtures thereof;
• xx) a unit having the formula:
• —CH═NOR16
• wherein R16 is hydrogen;
• C1-C12 linear or branched alkyl;
• C7-C22 linear or branched alkylenearyl;
• acyl having the formula —COR17, R17 is C1-C4 alkyl;
• or mixtures thereof;
• xxi) an amino unit having the formula:
• —(CH2)mN(R3)2
• wherein each R3 is independently C1-C18 substituted or unsubstituted, linear or branched alkyl;
• m is from 0 to 10;
• xxii) a quaternary ammonium unit having the formula:
• wherein each R3 is independently C1-C18 substituted or unsubstituted, linear or branched alkyl;
• Y is an anion of sufficient charge to provide electronic neutrality;
• m is from 0 to 10;
• o) two R units on the same carbon atom can be taken together to form a carbonyl unit or carbonyl unit equivalent;
• and
• p) mixtures thereof;
• L is a linking group;
• [Poly] is a polymeric unit, i indicates the number of said heterocyclic units which comprise said conjugate and has the value of from 1 to 100;
• z is 0 or 1;
• and
• b) the balance carriers and adjunct ingredients.