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US 6,723,749 B2Granted
Fatty acid synthase inhibitors
AssigneeSmithKline Beecham Corporation
InventorsSiegfried B. Christensen, Daniel J. Mercer, Jia-Ning Xiang
Life of this patent
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Abstract
This invention relates to the use of compounds as inhibitors of the fatty acid synthase FabH.
Claims4
A compound according to Formula (I):
- wherein:
- R represents OH, or NHSO2R2;
- A represents NH or O;
- B represents O, or NR1;
- R1 represents Ar′alkyl, or AlkylCO;
- Ar and Ar′represent, independently, phenyl, thiophenyl, pyridinyl, or pyrimidinyl, all of which could be substituted with a substituting selected from the group consisting of:
- halo, including fluoro, bromo, chloro, iodo, NO2, CN, CO2R3, OR3, NR3R4, C1-10alkyl, C1-10alkoxy, aryloxy, arylalkoxy, and heteroaryloxy;
- R2 represents alkyl, Ar′alkyl, or Ar′;
- and
- R3 and R4 represent, independently, hydrogen, or C1-10alkyl;
- or a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable salt complex thereof.
8 more elements
Dependencies are inferred from the claim text.