Methods, pharmaceutical and therapeutic compostions for administering adenosine
OwnerEliezer Rapaportinventor
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Abstract
The invention discloses methods for the chronic administration of adenosine, which contrary to the acute delivery of the drug by injection or infusion, acts in desensitizing adenosine receptors towards the action of adenosine. The methods and oral compositions of adenosine triphosphate (ATP), which is degraded to adenosine in vivo, can be used in the treatment of disorders and diseases that are therapeutically targeted by agonists or antagonists of adenosine receptors. One example is the stimulation of lipolysis in achieving weight loss in humans and in the treatment of obesity.
Claims27
A method for treating overweight and/or obesity which comprises administering to a human suffering from overweight and/or obesity an effective amount of at least one member selected from the group consisting of:
- (a) a mixture of adenosine and inorganic phosphate;
- and/or (b) an adenine nucleotide wherein said adenine nucleotide contains adenosine moiety(ies) and phosphate moiety(ies) and undergoes rapid degradation to adenosine and inorganic phosphate.
A process for treating overweight and/or obesity which comprises administering to a human suffering from overweight and/or obesity an effective amount of at least one member selected from the group consisting of:
- (a) a mixture of adenosine and inorganic phosphate;
- and/or (b) an adenine nucleotide wherein said adenine nucleotide contains adenosine moiety(ies) and phosphate moiety(ies) and undergoes rapid degradation to adenosine and inorganic phosphate, whereby adenosine desensitizes adenosine receptors in said human.
Dependencies are inferred from the claim text.