Sulfonamide and carbamide derivatives of 6(5H)phenanthridinones and their uses

A compound of Formula I:

• or a pharmaceutically acceptable salt, hydrate, or prodrug thereof, wherein:
• R1 is hydrogen or halogen;
• R2 is hydrogen, hydroxyl, amino, nitroso, methyl, amino methyl or carboxylic acid;
• R4 is —QP and R3 is one of hydrogen, methyl, trifluoromethyl, nitro, amino, halogen and 1-piperazine,
• wherein Q is one of
• P is Z—(N(R5R6)), Z or a 5 or 6 membered substituted or unsubstituted aromatic or non-aromatic ring which contains 0, 1, or 2 heteroatoms selected from the group consisting of O, N, S,
• wherein A is carbon or S═O,
• X is S or N;
• provided that,
• when X is S, then Y is absent,
• when X is N, then Y is hydrogen, C1-C6 straight or branched chain alkyl, optionally substituted alkoxy or alkyl amino, or Y and Z are taken together to form a 5, 6 or 7 membered substituted or unsubstituted heterocyclic aromatic or non-aromatic ring which contains 1, 2 or 3 heteroatoms selected from O, N, S and mixtures combination;
• Z is hydrogen, a direct bond, a carbonyl, an optionally substituted C1-C5 straight or branched chain alkyl, cycloalkyl, carboxy, optionally substituted C1-C6 ether, aryl or heteroaryl, alkylalkenyl, alkynyl, alkylhalo, straight or branched chain or CH2COOH, provided that when P is Z, Z is not hydrogen or a direct bond or a carbonyl and
• R5 and R6 are independently hydrogen, lower alkyl, lower alkenyl, lower alkanol, heterocycle, heteroaryl, alkoxy, aryloxy, alkylamino, arylamino, CH2COOH, or R5 and R6 taken together form a 5, 6 or 7 membered substituted or unsubstituted heterocyclic ring containing 1, 2 or 3 heteroatoms selected from O, N, S and combinations thereof.