# US 6,723,732 B1 · Percutaneously adminstrable preparations containing cerebral function activators

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- Number: US 6,723,732 B1
- Document ID: US6723732B1
- Status: Granted
- Kind: B1
- Application number: 09/830,113
- Filed: 2001-07-19
- Granted: 2004-04-20
- Earliest claimed: 1998-11-17
- Assignees: Shionogi & Co., Ltd.
- Inventors: Katsuji Sugita; Yoshitaka Nishihara; Takayoshi Yoshikawa
- Web page: https://patentgrep.com/patent/US6723732B1

## CPC

- A61K 47/14: Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 31/437: the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A61K 47/10: Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

The present invention provides a percutaneously administrable preparation comprising either an aqueous base comprising 1-menthol, a lower alcohol and an acidic buffer or water, or an oily base comprising 1-menthol, a lower alcohol and isopropyl myristate, and a cerebral function activator, for example, 2-(3-isoxazolyl)-3,6,7,9-tetrahydroimidazo[4,5-d]pyrano[4,3-b]pyridine, pharmaceutically acceptable salt or hydrate thereof.

## Claims

### Claim 1

A percutaneously administrable preparation which comprises 2-(3-isoxazolyl)-3,6,7,9-tetrahydroimidazo[4,5-d]pyrano[4,3-b]pyridine, pharmaceutically acceptable salt or hydrate thereof and an aqueous base wherein 1-menthol is 2 to 3% by weight, ethanol is 20 to 30% by weight, a phosphate buffer wherein pH is 3 to 5 is 60 to 80% by weight, each percentage being with respect to the total amount of the base.

### Claim 2 (depends on 1)

The percutaneously administrable preparation as claimed in claim 1 wherein 2-(3-isoxazolyl)-3,6,7,9-tetrahydroimidazo[4,5-d]pyrano[4,3-b]pyridine, pharmaceutically acceptable salt or hydrate thereof is 2-(3-isoxazolyl)-3,6,7,9-tetrahydroimidazo[4,5-d]pyrano[4,3-b]pyridine phosphate or hydrate thereof.