Substituted purine derivatives, processes for their preparation, their use, and compositions comprising them

A compound of the formula I:

• in which:
• X is hydrogen;
• Y is hydrogen;
• G is a radical of the formula II
• —(CR1R2)n—A—(CR1R2)m—(CR1R3)i—(CR1R2)q—R4 (II);
• W is a radical of the formula III
• —B—(CR1R2)r—A′—(CR1R2)s—(CR1R3)k—(CR1R2)t—D—E (III);
• A, A′ are a direct bond;
• R1, R2 independently of one another are hydrogen or (C1-C2)-alkyl;
• R3 is R6R6′N—R7, R6OC(O)N(R5)R7, R6SO2N(R5)R7, R6C(O)N(R5)R7, or R6N(R6′)C(O)N(R5)R7;
• R4 is C(O)R8;
• R5 is hydrogen or (C1-C2)-alkyl;
• R6, R6′ independently of one another are hydrogen, (C1-C18)-alkyl, (C3-C12)-cycloalkyl, (C3-C12)-cycloalkyl-(C1-C8)-alkyl, (C5-C14)-aryl, in which 1 to 3 carbon atoms can be replaced by 1 to 3 heteroatoms selected from the group consisting of N, S, and O, or are (C5-C14)-aryl-(C1-C8)-alkyl, in which 1 to 3 carbon atoms in aryl radicals can be replaced by 1 to 3 heteroatoms selected from the group consisting of N, S, and O, and where R6 and R6′, together with the atoms connecting them, can form a ring system which can optionally also contain additional heteroatoms selected from the group consisting of N, S, and O;
• R7 is a direct bond;
• R8 is hydroxyl, (C1-C4)-alkoxy, (C5-C14)-aryl-(C1-C4)-alkoxy, (C5-C14)-aryloxy, (C1-C8)-alkylcarbonyloxy(C1-C4)-alkoxy, or (C5-C14)-aryl-(C1-C4)-alkylcarbonyloxy-(C1-C4)-alkoxy;
• B is 1,4-piperidinediyl, where the nitrogen atom of the piperidine is bonded to the purine structure;
• D is —NR6— or —C(O)—NR6—, where in the group —C(O)—NR6— the nitrogen atom is bonded to the group E;
• E is R6R6′N—C(═NR6′)— or a radical selected from the group consisting of
• and which can optionally be monosubstituted, disubsitituted or trisubstituted by radicals selected from the group consisting of R3, R5, ═O, ═S, and R6R6′N—C(═NR6)—;
• r is zero or one;
• s is zero;
• t is zero;
• k is zero;
• n is one;
• m is zero;
• i is one;
• q is zero;
• in all its stereoisomeric forms and mixtures thereof in all ratios, and its physiologically tolerable salts.