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US 6,723,710 B2Granted
Compositions for inhibiting arginase activity
AssigneeThe Trustees of the University of Pennsylvania
InventorsDavid Christianson, Ricky Baggio, Daniel Elbaum
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Abstract
Compositions and methods for inhibiting arginase activity, including arginase activity in a mammal, are provided. Methods of making the compositions of the invention are also provided as are methods of using the compositions therapeutically. The compositions described herein are useful for alleviating or inhibiting a variety of arinase- and NO synthase-related disorders, including heart disease, gastrointestinal motility disorders, and penile erectile dysfunction in humans.
Claims2
A composition comprising an arginase inhibitor having the structure
- HOOC—CH(NH2)—X1—X2—X3—X4—B(OH)2
- wherein each of X1, X2, X3, and X4 is selected from the group consisting of —(CH2)—, —S—, —O—, —(NH)—, and —(N-alkyl)-, except that at least one of X1, X2, X3, and X4 is not —(CH2)— and X2 is not —S— when each of X1, X3, and X4 is —(CH2)—.
Dependencies are inferred from the claim text.