Use of insulin-like growth factor-I in muscle
AssigneesThe Trustees of the University of Pennsylvania, Massachusetts General Hospital
InventorsH. Lee Sweeney, Nadia A. Rosenthal
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Abstract
The invention relates compositions and method for the use of insulin-like growth factor to enhance muscle mass and strength.
Claims13
An isolated nucleic acid comprising a vertebrate Insulin-like Growth Factor I (IGF-I) coding region, operably linked to a muscle specific promoter/regulatory region, wherein said IGF-I coding region is flanked on the 5′ side by an SV40 intron sequence and wherein said IGF-I coding region is flanked on the 3′ end by an SV40 polyadenylation signal sequence.
A method of increasing vertebrate muscle mass and muscle strength, said method comprising administering a muscle enhancing dose of an isolated nucleic acid encoding Insulin-like Growth Factor I (IGF-I) intramuscularly into a vertebrate, wherein said isolated nucleic acid is expressed in muscle cells, thereby increasing said muscle mass and said muscle strength in said vertebrate, wherein said method further comprising administering to said vertebrate fibroblast growth factor or neurotropin.
Dependencies are inferred from the claim text.